Use of Bovine Milk Concentrate Containing Antibody to Rotavirus to Treat Rotavirus Gastroenteritis in Infants

The use of a concentrate containing milk immunoglobulins prepared from rotavirus-hyperimmunized cows (neutralization titer, 1:6,000 for a 10% solution) to treat infants hospitalized for acute rotavirus gastroenteritis resulted in a significant (P = .008) reduction in the duration of excretion of vir...

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Veröffentlicht in:	The Journal of infectious diseases 1987-07, Vol.156 (1), p.158-166
Hauptverfasser:	Hilpert, Helmut, Briissow, Harald, Mietens, Carl, Sidoti, Josette, Lerner, Lothar, Werchau, Hermann
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Viral - analysis Antibodies, Viral - immunology Biological and medical sciences Cattle Child, Preschool Children Diarrhea Enzyme-Linked Immunosorbent Assay Excretion Feces - microbiology Female Gastroenteritis Gastroenteritis - therapy Human viral diseases Humans Immunization, Passive Immunoglobulins Immunoglobulins - analysis Infant Infant, Newborn Infants Infectious diseases Male Medical sciences Milk - immunology Neutralization Tests Original Articles Pepsin A - pharmacology Rotavirus Rotavirus Infections - therapy Ungulates Viral diseases Viral diseases of the digestive system Viruses
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Zusammenfassung:	The use of a concentrate containing milk immunoglobulins prepared from rotavirus-hyperimmunized cows (neutralization titer, 1:6,000 for a 10% solution) to treat infants hospitalized for acute rotavirus gastroenteritis resulted in a significant (P = .008) reduction in the duration of excretion of virus. Stool samples from treated infants showed the presence of bovine milk immunoglobulins in 47% of cases and of neutralizing activity in 43% (mean neutralization titer, 1:48); stool samples from control infants showed neutralizing activities in only 3% of cases (neutralization titers,
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/156.1.158