Effects of dimethyl sulfoxide on systemic and cerebral hemodynamic variables in the ischemic canine myocardium
The effects of dimethyl sulfoxide (DMSO) infusion on cerebral blood flow (CBF) and systemic hemodynamics were studied in a canine model of myocardial ischemia. Immediately after ligation, cardiac output dropped from 2.09 ± 0.11 (SEM) in the control group and 1.79 ± 0.13 in the DMSO group to 1.07 ± 0...
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| Veröffentlicht in: | Critical care medicine 1987-07, Vol.15 (7), p.656-660 |
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| container_title | Critical care medicine |
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| creator | LEVETT, JAMES M JOHNS, LYDIA M GRINA, NORA M MULLAN, BRIAN F KRAMER, JOHN F MULLAN, JOHN F |
| description | The effects of dimethyl sulfoxide (DMSO) infusion on cerebral blood flow (CBF) and systemic hemodynamics were studied in a canine model of myocardial ischemia. Immediately after ligation, cardiac output dropped from 2.09 ± 0.11 (SEM) in the control group and 1.79 ± 0.13 in the DMSO group to 1.07 ± 0.21 and 1.0 ± 0.08 L/min, respectively; there were no significant differences for 2 h. By the third hour and thereafter, the DMSO group had a significantly (p < .05) higher cardiac output (1.65 ± 0.08 L/min) than the control group (1.15 ± 0.10 L/min). The cardiac output increase at 3 h was accompanied by significantly (p |
| doi_str_mv | 10.1097/00003246-198707000-00006 |
| format | Article |
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Immediately after ligation, cardiac output dropped from 2.09 ± 0.11 (SEM) in the control group and 1.79 ± 0.13 in the DMSO group to 1.07 ± 0.21 and 1.0 ± 0.08 L/min, respectively; there were no significant differences for 2 h. By the third hour and thereafter, the DMSO group had a significantly (p < .05) higher cardiac output (1.65 ± 0.08 L/min) than the control group (1.15 ± 0.10 L/min). The cardiac output increase at 3 h was accompanied by significantly (p <.05) lower systemic vascular resistance (SVR) in the DMSO group (5315 ± 248 dyne · sec/cm) as compared to the control group (7892 ± 442 dyne · sec/cm). There were no significant differences in heart rate, mean arterial pressure, pulmonary artery wedge pressure, or cerebral or pulmonary resistances in the control as compared to the DMSO group. Higher CBF values were noted at one hour and thereafter in the DMSO as compared to the control group (p < .05). Low-dose DMSO given as an iv bolus improved cardiac output and CBF and lowered SVR in this canine model of experimental myocardial ischemia.</description><identifier>ISSN: 0090-3493</identifier><identifier>EISSN: 1530-0293</identifier><identifier>DOI: 10.1097/00003246-198707000-00006</identifier><identifier>PMID: 3595155</identifier><identifier>CODEN: CCMDC7</identifier><language>eng</language><publisher>Hagerstown, MD: Williams & Wilkins</publisher><subject>Animals ; Antianginal agents. Coronary vasodilator agents ; Biological and medical sciences ; Blood Pressure - drug effects ; Cardiac Output - drug effects ; Cardiovascular system ; Cerebrovascular Circulation - drug effects ; Coronary Disease - physiopathology ; Dimethyl Sulfoxide - pharmacology ; Dogs ; Hemodynamics - drug effects ; Medical sciences ; Pharmacology. Drug treatments ; Vascular Resistance - drug effects</subject><ispartof>Critical care medicine, 1987-07, Vol.15 (7), p.656-660</ispartof><rights>Williams & Wilkins 1987. All Rights Reserved.</rights><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2996-19a6d23f0c79446919b397ff139632bf1936c14cf2363a905d6ce608fd36ae433</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7623049$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3595155$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LEVETT, JAMES M</creatorcontrib><creatorcontrib>JOHNS, LYDIA M</creatorcontrib><creatorcontrib>GRINA, NORA M</creatorcontrib><creatorcontrib>MULLAN, BRIAN F</creatorcontrib><creatorcontrib>KRAMER, JOHN F</creatorcontrib><creatorcontrib>MULLAN, JOHN F</creatorcontrib><title>Effects of dimethyl sulfoxide on systemic and cerebral hemodynamic variables in the ischemic canine myocardium</title><title>Critical care medicine</title><addtitle>Crit Care Med</addtitle><description>The effects of dimethyl sulfoxide (DMSO) infusion on cerebral blood flow (CBF) and systemic hemodynamics were studied in a canine model of myocardial ischemia. Immediately after ligation, cardiac output dropped from 2.09 ± 0.11 (SEM) in the control group and 1.79 ± 0.13 in the DMSO group to 1.07 ± 0.21 and 1.0 ± 0.08 L/min, respectively; there were no significant differences for 2 h. By the third hour and thereafter, the DMSO group had a significantly (p < .05) higher cardiac output (1.65 ± 0.08 L/min) than the control group (1.15 ± 0.10 L/min). The cardiac output increase at 3 h was accompanied by significantly (p <.05) lower systemic vascular resistance (SVR) in the DMSO group (5315 ± 248 dyne · sec/cm) as compared to the control group (7892 ± 442 dyne · sec/cm). There were no significant differences in heart rate, mean arterial pressure, pulmonary artery wedge pressure, or cerebral or pulmonary resistances in the control as compared to the DMSO group. Higher CBF values were noted at one hour and thereafter in the DMSO as compared to the control group (p < .05). Low-dose DMSO given as an iv bolus improved cardiac output and CBF and lowered SVR in this canine model of experimental myocardial ischemia.</description><subject>Animals</subject><subject>Antianginal agents. Coronary vasodilator agents</subject><subject>Biological and medical sciences</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Output - drug effects</subject><subject>Cardiovascular system</subject><subject>Cerebrovascular Circulation - drug effects</subject><subject>Coronary Disease - physiopathology</subject><subject>Dimethyl Sulfoxide - pharmacology</subject><subject>Dogs</subject><subject>Hemodynamics - drug effects</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Vascular Resistance - drug effects</subject><issn>0090-3493</issn><issn>1530-0293</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UUtv3CAQRlGrdLvNT6jEIerNLXhsMMcqSh9SpF6aM8IwyLQYp2A39b-PN7vZW7mg-R4z8A0hlLOPnCn5iW0H6kZUXHWSya2qDpC4IDvewlbUCl6RHWOKVdAoeEPelvKLMd60Ei7JJbSq5W27I-nWe7RzoZOnLow4D2ukZYl--hcc0inRspYZx2CpSY5azNhnE-mA4-TWZA7EX5OD6SMWGhKdB6Sh2OHZYk0KCem4TtZkF5bxHXntTSx4dbr35P7L7c-bb9Xdj6_fbz7fVbZW6vArI1wNnlmpmkYornpQ0nsOSkDde65AWN5YX4MAo1jrhEXBOu9AGGwA9uTDse9Dnv4sWGY9bo_CGE3CaSlayrYTErpN2B2FNk-lZPT6IYfR5FVzpg9R65eo9TnqZ0hs1venGUs_ojsbT9lu_PWJN8Wa6LNJNpSzTIoa2LaaPWmOsscpzpjL77g8YtYDmjgP-n-LhifnlpZ4</recordid><startdate>198707</startdate><enddate>198707</enddate><creator>LEVETT, JAMES M</creator><creator>JOHNS, LYDIA M</creator><creator>GRINA, NORA M</creator><creator>MULLAN, BRIAN F</creator><creator>KRAMER, JOHN F</creator><creator>MULLAN, JOHN F</creator><general>Williams & Wilkins</general><general>Lippincott</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198707</creationdate><title>Effects of dimethyl sulfoxide on systemic and cerebral hemodynamic variables in the ischemic canine myocardium</title><author>LEVETT, JAMES M ; JOHNS, LYDIA M ; GRINA, NORA M ; MULLAN, BRIAN F ; KRAMER, JOHN F ; MULLAN, JOHN F</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2996-19a6d23f0c79446919b397ff139632bf1936c14cf2363a905d6ce608fd36ae433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Animals</topic><topic>Antianginal agents. Coronary vasodilator agents</topic><topic>Biological and medical sciences</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiac Output - drug effects</topic><topic>Cardiovascular system</topic><topic>Cerebrovascular Circulation - drug effects</topic><topic>Coronary Disease - physiopathology</topic><topic>Dimethyl Sulfoxide - pharmacology</topic><topic>Dogs</topic><topic>Hemodynamics - drug effects</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Vascular Resistance - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LEVETT, JAMES M</creatorcontrib><creatorcontrib>JOHNS, LYDIA M</creatorcontrib><creatorcontrib>GRINA, NORA M</creatorcontrib><creatorcontrib>MULLAN, BRIAN F</creatorcontrib><creatorcontrib>KRAMER, JOHN F</creatorcontrib><creatorcontrib>MULLAN, JOHN F</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Critical care medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LEVETT, JAMES M</au><au>JOHNS, LYDIA M</au><au>GRINA, NORA M</au><au>MULLAN, BRIAN F</au><au>KRAMER, JOHN F</au><au>MULLAN, JOHN F</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of dimethyl sulfoxide on systemic and cerebral hemodynamic variables in the ischemic canine myocardium</atitle><jtitle>Critical care medicine</jtitle><addtitle>Crit Care Med</addtitle><date>1987-07</date><risdate>1987</risdate><volume>15</volume><issue>7</issue><spage>656</spage><epage>660</epage><pages>656-660</pages><issn>0090-3493</issn><eissn>1530-0293</eissn><coden>CCMDC7</coden><abstract>The effects of dimethyl sulfoxide (DMSO) infusion on cerebral blood flow (CBF) and systemic hemodynamics were studied in a canine model of myocardial ischemia. Immediately after ligation, cardiac output dropped from 2.09 ± 0.11 (SEM) in the control group and 1.79 ± 0.13 in the DMSO group to 1.07 ± 0.21 and 1.0 ± 0.08 L/min, respectively; there were no significant differences for 2 h. By the third hour and thereafter, the DMSO group had a significantly (p < .05) higher cardiac output (1.65 ± 0.08 L/min) than the control group (1.15 ± 0.10 L/min). The cardiac output increase at 3 h was accompanied by significantly (p <.05) lower systemic vascular resistance (SVR) in the DMSO group (5315 ± 248 dyne · sec/cm) as compared to the control group (7892 ± 442 dyne · sec/cm). There were no significant differences in heart rate, mean arterial pressure, pulmonary artery wedge pressure, or cerebral or pulmonary resistances in the control as compared to the DMSO group. Higher CBF values were noted at one hour and thereafter in the DMSO as compared to the control group (p < .05). Low-dose DMSO given as an iv bolus improved cardiac output and CBF and lowered SVR in this canine model of experimental myocardial ischemia.</abstract><cop>Hagerstown, MD</cop><pub>Williams & Wilkins</pub><pmid>3595155</pmid><doi>10.1097/00003246-198707000-00006</doi><tpages>5</tpages></addata></record> |
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| ispartof | Critical care medicine, 1987-07, Vol.15 (7), p.656-660 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Blood Pressure - drug effects Cardiac Output - drug effects Cardiovascular system Cerebrovascular Circulation - drug effects Coronary Disease - physiopathology Dimethyl Sulfoxide - pharmacology Dogs Hemodynamics - drug effects Medical sciences Pharmacology. Drug treatments Vascular Resistance - drug effects |
| title | Effects of dimethyl sulfoxide on systemic and cerebral hemodynamic variables in the ischemic canine myocardium |
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