Effects of dimethyl sulfoxide on systemic and cerebral hemodynamic variables in the ischemic canine myocardium

The effects of dimethyl sulfoxide (DMSO) infusion on cerebral blood flow (CBF) and systemic hemodynamics were studied in a canine model of myocardial ischemia. Immediately after ligation, cardiac output dropped from 2.09 ± 0.11 (SEM) in the control group and 1.79 ± 0.13 in the DMSO group to 1.07 ± 0...

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Veröffentlicht in:	Critical care medicine 1987-07, Vol.15 (7), p.656-660
Hauptverfasser:	LEVETT, JAMES M, JOHNS, LYDIA M, GRINA, NORA M, MULLAN, BRIAN F, KRAMER, JOHN F, MULLAN, JOHN F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Blood Pressure - drug effects Cardiac Output - drug effects Cardiovascular system Cerebrovascular Circulation - drug effects Coronary Disease - physiopathology Dimethyl Sulfoxide - pharmacology Dogs Hemodynamics - drug effects Medical sciences Pharmacology. Drug treatments Vascular Resistance - drug effects
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Zusammenfassung:	The effects of dimethyl sulfoxide (DMSO) infusion on cerebral blood flow (CBF) and systemic hemodynamics were studied in a canine model of myocardial ischemia. Immediately after ligation, cardiac output dropped from 2.09 ± 0.11 (SEM) in the control group and 1.79 ± 0.13 in the DMSO group to 1.07 ± 0.21 and 1.0 ± 0.08 L/min, respectively; there were no significant differences for 2 h. By the third hour and thereafter, the DMSO group had a significantly (p < .05) higher cardiac output (1.65 ± 0.08 L/min) than the control group (1.15 ± 0.10 L/min). The cardiac output increase at 3 h was accompanied by significantly (p
ISSN:	0090-3493 1530-0293
DOI:	10.1097/00003246-198707000-00006