d-Galactosamine induced changes in rat liver plasma membranes lipid composition and some enzyme activities

1. 1. The influence of d-galactosamine administration on rat liver plasma membranes lipid composition, fluidity and some enzyme activities was investigated. 2. 2. d-Galactosamine was found to induce an increase of the total phospholipids, the cholesterol level and membrane rigidity. 3. 3. In liver p...

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Veröffentlicht in:	International journal of biochemistry 1987, Vol.19 (3), p.289-291
Hauptverfasser:	Petkova, D.H., Momchilova, A.B., Markovska, T.T., Koumanov, K.S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Membrane - drug effects Cell Membrane - metabolism Cholesterol - metabolism galactosamine Galactosamine - pharmacology lipids liver Liver - drug effects Liver - metabolism Male Membrane Lipids - metabolism Phospholipases - metabolism Phospholipases A - metabolism Phospholipases A2 Phospholipids - metabolism Phosphoric Diester Hydrolases - metabolism Rats Rats, Inbred Strains Sphingomyelin Phosphodiesterase - metabolism
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Zusammenfassung:	1. 1. The influence of d-galactosamine administration on rat liver plasma membranes lipid composition, fluidity and some enzyme activities was investigated. 2. 2. d-Galactosamine was found to induce an increase of the total phospholipids, the cholesterol level and membrane rigidity. 3. 3. In liver plasma membranes of d-galactosamine-treated rats the exogenous phospholipase A 2 activity was enhanced about 2 fold, whereas the endogenous activity was slightly decreased. No alteration of the neutral sphingomyelinase activity was observed.
ISSN:	0020-711X
DOI:	10.1016/0020-711X(87)90034-6