A pituitary-specific trans-acting factor can stimulate transcription from the growth hormone promoter in extracts of nonexpressing cells

The growth hormone (GH) gene is specifically expressed in the anterior pituitary. The first 289 bp of the human (h)GH 5′ region contains a promoter that is active only in pituitary-derived cell lines. These cell lines also contain a specific factor, GHF-1, that binds to two sites upstream to the hGH...

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Veröffentlicht in:	Cell 1987-07, Vol.50 (2), p.267-275
Hauptverfasser:	Bodner, Mordechai, Karin, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Line Fundamental and applied biological sciences. Psychology Genes Growth Hormone - genetics HeLa Cells - drug effects Humans Molecular and cellular biology Molecular genetics Mutation Pituitary Gland, Anterior - metabolism Pituitary Neoplasms Promoter Regions, Genetic Rats Templates, Genetic Transcription Factors - physiology Transcription, Genetic - drug effects Transcription. Transcription factor. Splicing. Rna processing
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