The determination of palladium in fosinopril sodium (monopril) by ICP-MS

A rapid, sensitive ICP-MS method was developed to determine palladium in fosinopril sodium. The assay could not be carried out in a purely aqueous solvent owing to the instability of the palladium species in this media. It was found that the most appropriate vehcile for solubilization of this materi...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 1995-06, Vol.13 (7), p.879-883
Hauptverfasser:	Lewen, Nancy, Schenkenberger, Martha, Larkin, Timothy, Conder, Stephen, Brittain, Harry G
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiotensin-Converting Enzyme Inhibitors - chemistry Biological and medical sciences Drug Contamination Fosinopril - chemistry Fosinopril sodium General pharmacology ICP-MS Linear Models Mass Spectrometry - methods Medical sciences Monopril Palladium Palladium - analysis Pharmacology. Drug treatments Reproducibility of Results Sensitivity and Specificity Solvents
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Zusammenfassung:	A rapid, sensitive ICP-MS method was developed to determine palladium in fosinopril sodium. The assay could not be carried out in a purely aqueous solvent owing to the instability of the palladium species in this media. It was found that the most appropriate vehcile for solubilization of this material was a solution of 25% (v/v) 2-butoxyethanol and water. A minimum quantifiable limit of 0.1 μm g −1 for Pd in the sample (corresponding to 1 ng Pd mL −1 in the analyte solution) was obtained.
ISSN:	0731-7085 1873-264X
DOI:	10.1016/0731-7085(95)01501-B