Role of thrombin in pulmonary fibrosis
Pulmonary fibrosis commonly develops in systemic sclerosis. We assessed the role of thrombin in promoting fibroblast proliferation in the lungs in this disorder. Bronchoalveolar lavage fluid (BALF) thrombin concentrations were higher in ten patients with systemic sclerosis than in 12 healthy control...
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| Veröffentlicht in: | The Lancet (British edition) 1995-10, Vol.346 (8982), p.1071-1073 |
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| creator | Hernández-Rodríguez, N.A. Cambrey, A.D. Chambers, R.C. Gray, A.J. McAnulty, R.J. Laurent, G.J. Harrison, N.K. Southcott, A.M. duBois, R.M. Black, C.M. Scully, M.F. |
| description | Pulmonary fibrosis commonly develops in systemic sclerosis. We assessed the role of thrombin in promoting fibroblast proliferation in the lungs in this disorder. Bronchoalveolar lavage fluid (BALF) thrombin concentrations were higher in ten patients with systemic sclerosis than in 12 healthy controls (14·6 vs3·6 nmol/L, p |
| doi_str_mv | 10.1016/S0140-6736(95)91744-6 |
| format | Article |
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We assessed the role of thrombin in promoting fibroblast proliferation in the lungs in this disorder. Bronchoalveolar lavage fluid (BALF) thrombin concentrations were higher in ten patients with systemic sclerosis than in 12 healthy controls (14·6 vs3·6 nmol/L, p<0·02), but values in patients with cryptogenic fibrosing alveolitis (n=10) or sarcoldosis (n=10) were not increased. BALF from all patients induced fibroblast proliferation. This proliferation was attenuated by thrombin inhibitors for BALF from systemic sclerosis patients only. We suggest thrombin contributes to lung fibroblast proliferation in this disorder.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(95)91744-6</identifier><identifier>PMID: 7564789</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Alveoli ; Alveolitis ; Alveolitis, Extrinsic Allergic - etiology ; Alveolitis, Extrinsic Allergic - pathology ; Amino Acid Chloromethyl Ketones - pharmacology ; Antithrombins - pharmacology ; Biological and medical sciences ; Bronchoalveolar Lavage Fluid - cytology ; Bronchus ; Cardiovascular disease ; Cell Division - physiology ; Cryptogenic fibrosing alveolitis ; Fibroblasts ; Fibroblasts - physiology ; Fibrosis ; Hirudins - pharmacology ; Humans ; Lung diseases ; Lungs ; Medical research ; Medical sciences ; Pneumology ; Pulmonary fibrosis ; Pulmonary Fibrosis - etiology ; Pulmonary Fibrosis - pathology ; Respiratory system : syndromes and miscellaneous diseases ; Sarcoidosis - etiology ; Sarcoidosis - pathology ; Scleroderma ; Systemic sclerosis ; Thrombin ; Thrombin - physiology</subject><ispartof>The Lancet (British edition), 1995-10, Vol.346 (8982), p.1071-1073</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><rights>Copyright Lancet Ltd. Oct 21, 1995</rights><rights>Copyright Elsevier Limited Oct 21, 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c496t-53d18b79aaffcfe384442bc843f002c76630dab40a129e8f5495aff17d1dd17b3</citedby><cites>FETCH-LOGICAL-c496t-53d18b79aaffcfe384442bc843f002c76630dab40a129e8f5495aff17d1dd17b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0140673695917446$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3698829$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7564789$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hernández-Rodríguez, N.A.</creatorcontrib><creatorcontrib>Cambrey, A.D.</creatorcontrib><creatorcontrib>Chambers, R.C.</creatorcontrib><creatorcontrib>Gray, A.J.</creatorcontrib><creatorcontrib>McAnulty, R.J.</creatorcontrib><creatorcontrib>Laurent, G.J.</creatorcontrib><creatorcontrib>Harrison, N.K.</creatorcontrib><creatorcontrib>Southcott, A.M.</creatorcontrib><creatorcontrib>duBois, R.M.</creatorcontrib><creatorcontrib>Black, C.M.</creatorcontrib><creatorcontrib>Scully, M.F.</creatorcontrib><title>Role of thrombin in pulmonary fibrosis</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Pulmonary fibrosis commonly develops in systemic sclerosis. We assessed the role of thrombin in promoting fibroblast proliferation in the lungs in this disorder. Bronchoalveolar lavage fluid (BALF) thrombin concentrations were higher in ten patients with systemic sclerosis than in 12 healthy controls (14·6 vs3·6 nmol/L, p<0·02), but values in patients with cryptogenic fibrosing alveolitis (n=10) or sarcoldosis (n=10) were not increased. BALF from all patients induced fibroblast proliferation. This proliferation was attenuated by thrombin inhibitors for BALF from systemic sclerosis patients only. We suggest thrombin contributes to lung fibroblast proliferation in this disorder.</description><subject>Alveoli</subject><subject>Alveolitis</subject><subject>Alveolitis, Extrinsic Allergic - etiology</subject><subject>Alveolitis, Extrinsic Allergic - pathology</subject><subject>Amino Acid Chloromethyl Ketones - pharmacology</subject><subject>Antithrombins - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Bronchoalveolar Lavage Fluid - cytology</subject><subject>Bronchus</subject><subject>Cardiovascular disease</subject><subject>Cell Division - physiology</subject><subject>Cryptogenic fibrosing alveolitis</subject><subject>Fibroblasts</subject><subject>Fibroblasts - physiology</subject><subject>Fibrosis</subject><subject>Hirudins - pharmacology</subject><subject>Humans</subject><subject>Lung diseases</subject><subject>Lungs</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Pulmonary fibrosis</subject><subject>Pulmonary Fibrosis - 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Academic</collection><jtitle>The Lancet (British edition)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hernández-Rodríguez, N.A.</au><au>Cambrey, A.D.</au><au>Chambers, R.C.</au><au>Gray, A.J.</au><au>McAnulty, R.J.</au><au>Laurent, G.J.</au><au>Harrison, N.K.</au><au>Southcott, A.M.</au><au>duBois, R.M.</au><au>Black, C.M.</au><au>Scully, M.F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of thrombin in pulmonary fibrosis</atitle><jtitle>The Lancet (British edition)</jtitle><addtitle>Lancet</addtitle><date>1995-10-21</date><risdate>1995</risdate><volume>346</volume><issue>8982</issue><spage>1071</spage><epage>1073</epage><pages>1071-1073</pages><issn>0140-6736</issn><eissn>1474-547X</eissn><coden>LANCAO</coden><abstract>Pulmonary fibrosis commonly develops in systemic sclerosis. We assessed the role of thrombin in promoting fibroblast proliferation in the lungs in this disorder. Bronchoalveolar lavage fluid (BALF) thrombin concentrations were higher in ten patients with systemic sclerosis than in 12 healthy controls (14·6 vs3·6 nmol/L, p<0·02), but values in patients with cryptogenic fibrosing alveolitis (n=10) or sarcoldosis (n=10) were not increased. BALF from all patients induced fibroblast proliferation. This proliferation was attenuated by thrombin inhibitors for BALF from systemic sclerosis patients only. We suggest thrombin contributes to lung fibroblast proliferation in this disorder.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>7564789</pmid><doi>10.1016/S0140-6736(95)91744-6</doi><tpages>3</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 1995-10, Vol.346 (8982), p.1071-1073 |
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| subjects | Alveoli Alveolitis Alveolitis, Extrinsic Allergic - etiology Alveolitis, Extrinsic Allergic - pathology Amino Acid Chloromethyl Ketones - pharmacology Antithrombins - pharmacology Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Bronchus Cardiovascular disease Cell Division - physiology Cryptogenic fibrosing alveolitis Fibroblasts Fibroblasts - physiology Fibrosis Hirudins - pharmacology Humans Lung diseases Lungs Medical research Medical sciences Pneumology Pulmonary fibrosis Pulmonary Fibrosis - etiology Pulmonary Fibrosis - pathology Respiratory system : syndromes and miscellaneous diseases Sarcoidosis - etiology Sarcoidosis - pathology Scleroderma Systemic sclerosis Thrombin Thrombin - physiology |
| title | Role of thrombin in pulmonary fibrosis |
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