Role of thrombin in pulmonary fibrosis

Pulmonary fibrosis commonly develops in systemic sclerosis. We assessed the role of thrombin in promoting fibroblast proliferation in the lungs in this disorder. Bronchoalveolar lavage fluid (BALF) thrombin concentrations were higher in ten patients with systemic sclerosis than in 12 healthy control...

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Veröffentlicht in:	The Lancet (British edition) 1995-10, Vol.346 (8982), p.1071-1073
Hauptverfasser:	Hernández-Rodríguez, N.A., Cambrey, A.D., Chambers, R.C., Gray, A.J., McAnulty, R.J., Laurent, G.J., Harrison, N.K., Southcott, A.M., duBois, R.M., Black, C.M., Scully, M.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alveoli Alveolitis Alveolitis, Extrinsic Allergic - etiology Alveolitis, Extrinsic Allergic - pathology Amino Acid Chloromethyl Ketones - pharmacology Antithrombins - pharmacology Biological and medical sciences Bronchoalveolar Lavage Fluid - cytology Bronchus Cardiovascular disease Cell Division - physiology Cryptogenic fibrosing alveolitis Fibroblasts Fibroblasts - physiology Fibrosis Hirudins - pharmacology Humans Lung diseases Lungs Medical research Medical sciences Pneumology Pulmonary fibrosis Pulmonary Fibrosis - etiology Pulmonary Fibrosis - pathology Respiratory system : syndromes and miscellaneous diseases Sarcoidosis - etiology Sarcoidosis - pathology Scleroderma Systemic sclerosis Thrombin Thrombin - physiology
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Zusammenfassung:	Pulmonary fibrosis commonly develops in systemic sclerosis. We assessed the role of thrombin in promoting fibroblast proliferation in the lungs in this disorder. Bronchoalveolar lavage fluid (BALF) thrombin concentrations were higher in ten patients with systemic sclerosis than in 12 healthy controls (14·6 vs3·6 nmol/L, p
ISSN:	0140-6736 1474-547X
DOI:	10.1016/S0140-6736(95)91744-6