Studies on the effects of the narcotic alkaloids, cocaine, morphine, and codeine on nonenzymatic lipid peroxidation in rat brain mitochondria

This paper presents evidence of studies on the effects of the narcotic alkaloids, cocaine hydrochloride, morphine sulfate, and codeine phosphate, on nonenzymatic lipid peroxidation in rat brain mitochondria. These organelles abound in polyunsaturated fatty acids and are thus susceptible to oxidative...

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Veröffentlicht in:	Biochemical medicine and metabolic biology 1987-04, Vol.37 (2), p.258-264
Hauptverfasser:	Das, Nagaratnam P., Ratty, Anil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - pharmacology Animals Ascorbic Acid - pharmacology Biological and medical sciences Brain - cytology Brain - drug effects Brain - metabolism Cocaine - pharmacology Codeine - pharmacology Hypnotics. Sedatives Lipid Peroxides - metabolism Male Malondialdehyde - biosynthesis Medical sciences Mitochondria - drug effects Mitochondria - metabolism Morphine - pharmacology Neuropharmacology Pharmacology. Drug treatments Psychology. Psychoanalysis. Psychiatry Psychopharmacology Rats Rats, Inbred Strains Spectrometry, Fluorescence
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Beschreibung
Zusammenfassung:	This paper presents evidence of studies on the effects of the narcotic alkaloids, cocaine hydrochloride, morphine sulfate, and codeine phosphate, on nonenzymatic lipid peroxidation in rat brain mitochondria. These organelles abound in polyunsaturated fatty acids and are thus susceptible to oxidative attack. Lipid peroxidation was indexed mainly by assaying the extent of malonaldehyle (MDA) production and also the formation of fluorescent prducts in the course of the reaction.
ISSN:	0885-4505 1557-7651
DOI:	10.1016/0885-4505(87)90035-1