Inhibition of nitric oxide (NO •) production in murine macrophages by flavones

The effect of flavone (2-phenylbenzopyran-4-one) and three amino-substituted flavones on the production of nitrite by murine activated peritoneal macrophages was studied in vitro. Activated peritoneal macrophages obtained from mice pre-treated with concanavalin A (Con A) ( in vivo), after exposure i...

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Veröffentlicht in:	Biochemical pharmacology 1995-09, Vol.50 (7), p.1031-1035
Hauptverfasser:	Król, Wojciech, Czuba, Zenon P., Threadgill, Michael D., Cunningham, Bernadette D.M., Pietsz, Grazyna
Format:	Artikel
Sprache:	eng
Schlagworte:	3′-amino-4′-hydroxyflavone Animals Arginine - analogs & derivatives Arginine - pharmacology Biological and medical sciences Cell Survival Concanavalin A - administration & dosage Enzyme Inhibitors - pharmacology flavones Flavonoids - pharmacology General pharmacology Genistein Isoflavones - pharmacology Lipopolysaccharides macrophages Macrophages - drug effects Macrophages - metabolism Macrophages, Peritoneal - drug effects Male Medical sciences Mice Mice, Inbred BALB C nitric oxide Nitric Oxide - biosynthesis Nitric Oxide Synthase - antagonists & inhibitors Nitrites - analysis NO omega-N-Methylarginine Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments
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