A YAC contig map of the human genome

A YAC contig map of the human genome

A yeast artificial chromosome library containing 33,000 clones with an average insert size of one megabase of human genomic DNA was extensively analysed by several different procedures for detecting overlaps and positional information. We developed an analysis strategy that resulted, after confirmat...

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Veröffentlicht in:Nature (London) 1995-09, Vol.377 (6547 Suppl), p.175-175
Hauptverfasser: Chumakov, I M, Rigault, P, Le Gall, I, Bellanné-Chantelot, C, Billault, A, Guillou, S, Soularue, P, Guasconi, G, Poullier, E, Gros, I
Format: Artikel
Sprache:eng
Schlagworte:
Chromosome Mapping - methods
Chromosomes, Artificial, Yeast
Clones
Deoxyribonucleic acid
DNA
DNA Fingerprinting
Genes
Genetic Markers
Genetics
Genome, Human
Humans
In Situ Hybridization, Fluorescence
Nucleic Acid Hybridization
Sequence Tagged Sites
Yeast
Yeasts
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Zusammenfassung:A yeast artificial chromosome library containing 33,000 clones with an average insert size of one megabase of human genomic DNA was extensively analysed by several different procedures for detecting overlaps and positional information. We developed an analysis strategy that resulted, after confirmatory tests, in a YAC contig map reliably covering about 75% of the human genome in 225 contigs having an average size of about ten megabases.
ISSN:0028-0836
1476-4687