Oral Tetrahydroaminoacridine in the Treatment of Senile Dementia, Alzheimer's Type

To the Editor: The report by Summers et a!. (Nov. 13 issue)* contains methodologic problems that render the results difficult to interpret. First, the selection of outcome variables is inappropriate. The neuropsychological assessment techniques employed included the Luria–Nebraska Neuropsychological Test, the Minnesota Multiphasic Personality Inventory, the New York University Memory Test, Wechsler's Adult Intelligence Scale, the Mini Mental State test, three psychometric tests, and a subjective measure designed by the authors. The authors do not refer to the results of any tests except the four they designed. The psychometric properties and construct validity of these psychometric scales are unknown. It . . .