Effects of pregnancy on the cytochrome P-450 system in mice

The effects of pregnancy on the hepatic cytochrome P-450-dependent mixed-function mono-oxygenase system (P-450) from day 6 to day 18 of gestation were examined in the C57BL/6J mouse. Pregnancy induced an initial increase and then a decrease in total P-450 content, a decrease in microsomal aminopyrin...

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Veröffentlicht in:	Biochemical pharmacology 1987-06, Vol.36 (12), p.1965-1971
Hauptverfasser:	Lambert, George H., Lietz, Helen W., Kotake, Alvin N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopyrine N-Demethylase - metabolism Animals Biological and medical sciences Cytochrome P-450 Enzyme System - metabolism Diseases of mother, fetus and pregnancy Ethylmorphine-N-Demethylase - metabolism Female Gynecology. Andrology. Obstetrics Medical sciences Mice Mice, Inbred C57BL Mice, Inbred DBA Pregnancy Pregnancy, Animal - metabolism Pregnancy. Fetus. Placenta
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Zusammenfassung:	The effects of pregnancy on the hepatic cytochrome P-450-dependent mixed-function mono-oxygenase system (P-450) from day 6 to day 18 of gestation were examined in the C57BL/6J mouse. Pregnancy induced an initial increase and then a decrease in total P-450 content, a decrease in microsomal aminopyrine- N-demethylase activity, and had no effect on nucrosomal ethylmorphine- N-demethylase activity. Pregnancy also induced in the C57BL/6J and the DBA/2J mice a new major isozyme of P-450 (P-450 gest) as determined by high performance liquid chromatography and gel electrophoresis.
ISSN:	0006-2952 1873-2968
DOI:	10.1016/0006-2952(87)90495-3