Sexing the human pre-embryo by DNA-DNA in-situ hybridisation

Sexing the human pre-embryo by DNA-DNA in-situ hybridisation

Human male pre-embryos were identified by means of DNA-DNA in-situ hybridisation with a commercially available DNA probe for Y-chromosome DNA. This method could lead to prenatal diagnosis of genetic disorders based on small numbers of cells that are not necessarily in division, such as cells obtaine...

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Veröffentlicht in:The Lancet (British edition) 1987-06, Vol.1 (8546), p.1345-1347
Hauptverfasser: West, J D, Gosden, J R, Angell, R R, Hastie, N D, Thatcher, S S, Glasier, A F, Baird, D T
Format: Artikel
Sprache:eng
Schlagworte:
Autoradiography
DNA - analysis
Embryonic Development
Female
Fertilization in Vitro
Genetic Engineering - methods
Humans
Male
Nucleic Acid Hybridization
Pregnancy
Prenatal Diagnosis
Sex Preselection - methods
Y Chromosome - analysis
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Beschreibung
Zusammenfassung:Human male pre-embryos were identified by means of DNA-DNA in-situ hybridisation with a commercially available DNA probe for Y-chromosome DNA. This method could lead to prenatal diagnosis of genetic disorders based on small numbers of cells that are not necessarily in division, such as cells obtained from a pre-embryo during the course of in-vitro fertilisation therapy.
ISSN:0140-6736