Direct Enantiomeric Separation of Platelet-activating Factor Receptor Antagonist SM-10661 by Ligand-exchange High-performance Liquid Chromatography with a Copper(II) N,S-Dioctyl-D-penicillamine Complex

The enantiomeric separation of SM-10661, a platelet activating factor receptor antagonist, was investigated by HPLC using ligand-exchange chiral stationary phases. The stereoisomers of SM-10661 could all be separated by ligand-exchange HPLC with a Cu(II) N,S-dioctyl-D-penicillamine complex (Sumichir...

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Veröffentlicht in:	Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 1995-09, Vol.59 (9), p.1740-1741
Hauptverfasser:	Okamoto, Masahiko, Ueda, Youichi, Takahashi, Ken-ichi, Nakazawa, Hiroshi, Doi, Tadashi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biotechnology Blood. Blood coagulation. Reticuloendothelial system Cations Chromatography, High Pressure Liquid - methods Copper - chemistry Isomerism Medical sciences Penicillamine - chemistry Pharmacology. Drug treatments Platelet Membrane Glycoproteins - antagonists & inhibitors Platelet Membrane Glycoproteins - chemistry Receptors, Cell Surface Receptors, G-Protein-Coupled Thiazoles - chemistry Thiazolidines
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Beschreibung
Zusammenfassung:	The enantiomeric separation of SM-10661, a platelet activating factor receptor antagonist, was investigated by HPLC using ligand-exchange chiral stationary phases. The stereoisomers of SM-10661 could all be separated by ligand-exchange HPLC with a Cu(II) N,S-dioctyl-D-penicillamine complex (Sumichiral OA-5000). The mechanism for the resolution includes the involvement of hydrophobic interactions between SM-10661 and Cu(II) D-penicillamine.
ISSN:	0916-8451 1347-6947
DOI:	10.1271/bbb.59.1740