Sizing of a Vesicle Drug Formulation by Quasi-Elastic Light Scattering and Comparison with Electron Microscopy and Ultracentrifugation
Quasi-elastic light scattering has been used for the sizing of a vesicle formulation. Porcine insulin was encapsulated in a vesicle preparation containing cholesterol, dipalmitoylphosphotidylcholine, digalactosyl digycerides, and dipalmitoylphosphotidylglycerol in a 40:40:15:5 ratio. The measurement...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1987-01, Vol.76 (1), p.56-59 |
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| container_end_page | 59 |
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| container_title | Journal of pharmaceutical sciences |
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| creator | McCracken, M.S. Sammons, M.C. |
| description | Quasi-elastic light scattering has been used for the sizing of a vesicle formulation. Porcine insulin was encapsulated in a vesicle preparation containing cholesterol, dipalmitoylphosphotidylcholine, digalactosyl digycerides, and dipalmitoylphosphotidylglycerol in a 40:40:15:5 ratio. The measurement requires |
| doi_str_mv | 10.1002/jps.2600760116 |
| format | Article |
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Porcine insulin was encapsulated in a vesicle preparation containing cholesterol, dipalmitoylphosphotidylcholine, digalactosyl digycerides, and dipalmitoylphosphotidylglycerol in a 40:40:15:5 ratio. The measurement requires <15min to obtain mean size and distribution information and can be operated in a quality control environment. Advantages and limitations of quasi-elastic light scattering are described and this method is compared to electron microscopy and ultracentrifugation.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600760116</identifier><identifier>PMID: 3585725</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Biological and medical sciences ; Chemistry, Pharmaceutical ; Chromatography, Gel ; General pharmacology ; Light ; Medical sciences ; Microscopy, Electron ; Particle Size ; Pharmaceutical technology. 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Pharm. Sci</addtitle><description>Quasi-elastic light scattering has been used for the sizing of a vesicle formulation. Porcine insulin was encapsulated in a vesicle preparation containing cholesterol, dipalmitoylphosphotidylcholine, digalactosyl digycerides, and dipalmitoylphosphotidylglycerol in a 40:40:15:5 ratio. The measurement requires <15min to obtain mean size and distribution information and can be operated in a quality control environment. Advantages and limitations of quasi-elastic light scattering are described and this method is compared to electron microscopy and ultracentrifugation.</description><subject>Biological and medical sciences</subject><subject>Chemistry, Pharmaceutical</subject><subject>Chromatography, Gel</subject><subject>General pharmacology</subject><subject>Light</subject><subject>Medical sciences</subject><subject>Microscopy, Electron</subject><subject>Particle Size</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmaceutical Vehicles</subject><subject>Pharmacology. Drug treatments</subject><subject>Scattering, Radiation</subject><subject>Ultracentrifugation</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU9vEzEQxS0EKqFw5YbkA-K2wX_W9u4RpWkLClAU2h4tx_amLs7uYntpwwfgc-N0oyAOiJM1mt97M_MMwEuMphgh8va2j1PCERIcYcwfgQlmBBW5EI_BJAOkoKysn4JnMd4ihDhi7AgcUVYxQdgE_Fq6n65dw66BCl7Z6LS38CQMa3jahc3gVXJdC1db-GVQ0RVzr2JyGi7c-ibBpVYp2bDTq9bAWbfpVXAxC-5cuoFzb3UKufrodOii7vrtA3fpU1Datim4Zlg_THgOnjTKR_ti_x6Dy9P519l5sfh89n72blHoknFeCM1KLfIZGq8MZVSVjLEKCUIU1YQpruuaYFJzTImoarWqqtJYo5kxxBCu6DF4M_r2ofs-2JjkxkVtvVet7YYohWBllbPL4HQEd5vHYBvZB7dRYSsxkrvgZQ5e_gk-C17tnYfVxpoDvk8691_v-ypq5ZugWu3iAatIJSjd2dQjdue83f5nqPxwsfxrhWLUupjs_UGrwjfJBRVMXn86k_gCsesFvpJ15quRtznxH84GGbWzrbbGhfxz0nTuX9f-BrHuvsQ</recordid><startdate>198701</startdate><enddate>198701</enddate><creator>McCracken, M.S.</creator><creator>Sammons, M.C.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198701</creationdate><title>Sizing of a Vesicle Drug Formulation by Quasi-Elastic Light Scattering and Comparison with Electron Microscopy and Ultracentrifugation</title><author>McCracken, M.S. ; Sammons, M.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4566-7c54c7000c1bd353a455580722a3c25a6c9921296132789ab884dedc5dd2d26a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Biological and medical sciences</topic><topic>Chemistry, Pharmaceutical</topic><topic>Chromatography, Gel</topic><topic>General pharmacology</topic><topic>Light</topic><topic>Medical sciences</topic><topic>Microscopy, Electron</topic><topic>Particle Size</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmaceutical Vehicles</topic><topic>Pharmacology. Drug treatments</topic><topic>Scattering, Radiation</topic><topic>Ultracentrifugation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McCracken, M.S.</creatorcontrib><creatorcontrib>Sammons, M.C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McCracken, M.S.</au><au>Sammons, M.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sizing of a Vesicle Drug Formulation by Quasi-Elastic Light Scattering and Comparison with Electron Microscopy and Ultracentrifugation</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1987-01</date><risdate>1987</risdate><volume>76</volume><issue>1</issue><spage>56</spage><epage>59</epage><pages>56-59</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>Quasi-elastic light scattering has been used for the sizing of a vesicle formulation. Porcine insulin was encapsulated in a vesicle preparation containing cholesterol, dipalmitoylphosphotidylcholine, digalactosyl digycerides, and dipalmitoylphosphotidylglycerol in a 40:40:15:5 ratio. The measurement requires <15min to obtain mean size and distribution information and can be operated in a quality control environment. Advantages and limitations of quasi-elastic light scattering are described and this method is compared to electron microscopy and ultracentrifugation.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>3585725</pmid><doi>10.1002/jps.2600760116</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1987-01, Vol.76 (1), p.56-59 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77548017 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Chemistry, Pharmaceutical Chromatography, Gel General pharmacology Light Medical sciences Microscopy, Electron Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmaceutical Vehicles Pharmacology. Drug treatments Scattering, Radiation Ultracentrifugation |
| title | Sizing of a Vesicle Drug Formulation by Quasi-Elastic Light Scattering and Comparison with Electron Microscopy and Ultracentrifugation |
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