Sizing of a Vesicle Drug Formulation by Quasi-Elastic Light Scattering and Comparison with Electron Microscopy and Ultracentrifugation

Quasi-elastic light scattering has been used for the sizing of a vesicle formulation. Porcine insulin was encapsulated in a vesicle preparation containing cholesterol, dipalmitoylphosphotidylcholine, digalactosyl digycerides, and dipalmitoylphosphotidylglycerol in a 40:40:15:5 ratio. The measurement...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1987-01, Vol.76 (1), p.56-59
Hauptverfasser:	McCracken, M.S., Sammons, M.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chemistry, Pharmaceutical Chromatography, Gel General pharmacology Light Medical sciences Microscopy, Electron Particle Size Pharmaceutical technology. Pharmaceutical industry Pharmaceutical Vehicles Pharmacology. Drug treatments Scattering, Radiation Ultracentrifugation
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Zusammenfassung:	Quasi-elastic light scattering has been used for the sizing of a vesicle formulation. Porcine insulin was encapsulated in a vesicle preparation containing cholesterol, dipalmitoylphosphotidylcholine, digalactosyl digycerides, and dipalmitoylphosphotidylglycerol in a 40:40:15:5 ratio. The measurement requires
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600760116