OF4949, NEW INHIBITORS OF AMINOPEPTIDASE B: V. EFFECT ON THE MURINE IMMUNE SYSTEM

OF4949-I inhibited the growth of the solid form of IMC carcinoma and protected against pulmonary metastases of Lewis lung carcinoma. It also augmented the cytostatic activity of mouse peritoneal macrophages, the natural killer activity, and the antibody-dependent cell-mediated cytotoxicity of mouse...

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Veröffentlicht in:	Journal of antibiotics 1987/04/25, Vol.40(4), pp.519-525
Hauptverfasser:	SANO, SUSUMU, KURODA, HIROYUKI, UENO, MITSUHIRO, YOSHIKAWA, YOSHIE, NAKAMURA, TERUYA, OBAYASHI, AKIRA
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminopeptidases - antagonists & inhibitors Animals Antibody-Dependent Cell Cytotoxicity - drug effects Antineoplastic agents Biological and medical sciences Cell Line Cytotoxicity, Immunologic - drug effects Female General aspects Killer Cells, Natural - drug effects Killer Cells, Natural - immunology Lung Neoplasms - drug therapy Lymphocytes - drug effects Lymphocytes - immunology Macrophages - drug effects Macrophages - immunology Male Medical sciences Mice Mice, Inbred Strains Penicillium Peptides, Cyclic - pharmacology Peptides, Cyclic - therapeutic use Pharmacology. Drug treatments
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Zusammenfassung:	OF4949-I inhibited the growth of the solid form of IMC carcinoma and protected against pulmonary metastases of Lewis lung carcinoma. It also augmented the cytostatic activity of mouse peritoneal macrophages, the natural killer activity, and the antibody-dependent cell-mediated cytotoxicity of mouse spleen cells. This substance was not cytotoxic to cultured tumor or normal cells even at high concentrations. These results suggest that a cell-mediated immune response stimulated by this compound might account for its antitumor activity.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.40.519