MODIFICATION OF THE CYSTEAMINE SIDE CHAIN OF THIENAMYCIN. II

A new type of thienamycin derivatives (3a-3j, 4a, 4b), having a monothioacetal or a thioacetal side chain at the C-2 position was prepared, and the susceptibility to renal dehydropeptidase-1 (DHP-1) and the antimicrobial activity of these compounds were determined. The structure-activity relationshi...

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Veröffentlicht in:	Journal of antibiotics 1987/04/25, Vol.40(4), pp.483-495
Hauptverfasser:	SATO, MAKOTO, TAKEMURA, MAKOTO, ATARASHI, SHOHGO, HIGASHI, KUNIO, FUJIWARA, HIROYUKI, NAGAHARA, TAKAYASU, FURUKAWA, MINORU, IKEUCHI, TORU, OZAWA, SEIICHI, NISHIZAWA, NOBUKO, OSADA, YASUAKI
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria - drug effects Chemistry Cysteamine Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Indicators and Reagents Magnetic Resonance Spectroscopy Microbial Sensitivity Tests Organic chemistry Preparations and properties Spectrophotometry, Infrared Structure-Activity Relationship Thienamycins - chemical synthesis
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Zusammenfassung:	A new type of thienamycin derivatives (3a-3j, 4a, 4b), having a monothioacetal or a thioacetal side chain at the C-2 position was prepared, and the susceptibility to renal dehydropeptidase-1 (DHP-1) and the antimicrobial activity of these compounds were determined. The structure-activity relationships of these derivatives are also discussed.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.40.483