Neuroaxonal dystrophy in experimental creutzfeldt-jakob disease: Electron microscopical and immunohistochemical demonstration of neurofilament accumulations within affected neurites

Neuroaxonal dystrophy is a feature of neuronal degeneration encountered in all subacute spongiform “virus” encephalopathies, including scrapie and Creutzfeldt-Jakob disese (CJD). By immunohistochemical techniques, the accumulation of 200 kDa neurofilament protein was demonstrated in affected neurite...

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Veröffentlicht in:Journal of comparative pathology 1995-04, Vol.112 (3), p.243-255
Hauptverfasser: Liberski, P.P., Budka, H., Yanagihara, R., Gajdusek, D.C.
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Sprache:eng
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Zusammenfassung:Neuroaxonal dystrophy is a feature of neuronal degeneration encountered in all subacute spongiform “virus” encephalopathies, including scrapie and Creutzfeldt-Jakob disese (CJD). By immunohistochemical techniques, the accumulation of 200 kDa neurofilament protein was demonstrated in affected neurites in murine CJD. These neurites exhibited the ultrastructural features of dystrophic neurities encountered in other neurodegenerative disorders, particularly Alzheimer's disease. These findings support the hypothesis that impairment of slow axoplasmic transport is a common pathogenetic mechanism for CJD and many other neurodegenerative conditions.
ISSN:0021-9975
1532-3129
DOI:10.1016/S0021-9975(05)80078-7