Tumor suppression by p21WAF1

The p21WAF1 gene encodes a cyclin-dependent kinase inhibitor and mediates tumor suppressor gene p53-induced cell cycle arrest. To directly test whether p21WAF1 can act as a tumor suppressor, we have expressed the p21WAF1 cDNA in several human tumor cell lines using a tetracycline-inducible system. O...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1995-10, Vol.55 (20), p.4536-4539
Hauptverfasser:	CHEN, Y. Q, CIPRIANO, S. C, ARENKIEL, J. M, MILLER, F. R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cell Adhesion Cell Division Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cyclin-Dependent Kinase Inhibitor p21 Cyclins - physiology Fundamental and applied biological sciences. Psychology Genes, Tumor Suppressor Humans In Vitro Techniques Mice Mice, Nude Molecular and cellular biology Neoplasm Transplantation Neoplasms, Experimental - genetics Neoplasms, Experimental - pathology Transfection Tumor Cells, Cultured - pathology
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Zusammenfassung:	The p21WAF1 gene encodes a cyclin-dependent kinase inhibitor and mediates tumor suppressor gene p53-induced cell cycle arrest. To directly test whether p21WAF1 can act as a tumor suppressor, we have expressed the p21WAF1 cDNA in several human tumor cell lines using a tetracycline-inducible system. Overexpression of p21WAF1 suppresses proliferation and soft agar growth of tumor cells in vitro, as well as tumorigenicity in vivo. Our data provide direct evidence for the tumor-suppressive activity of p21WAF1.
ISSN:	0008-5472 1538-7445