Fluorouracil: Active in ZD1694 (Tomudex)-Resistant Cell Lines With Markedly Elevated Thymidylate Synthase Levels
A letter to the editor discusses ZD1694, which is a quinazoline folate that inhibits the catalytic activity of thymidylate synthase. ZD1694 has been safely administered to patients in trials.
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| Veröffentlicht in: | JNCI : Journal of the National Cancer Institute 1995-10, Vol.87 (20), p.1558-1559 |
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| container_end_page | 1559 |
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| container_issue | 20 |
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| container_title | JNCI : Journal of the National Cancer Institute |
| container_volume | 87 |
| creator | JOHNSTON, PATRICK G. BEHAN, KATHERINE A. ALLEGRA, CARMEN J. DRAKE, JAMES C. |
| description | A letter to the editor discusses ZD1694, which is a quinazoline folate that inhibits the catalytic activity of thymidylate synthase. ZD1694 has been safely administered to patients in trials. |
| doi_str_mv | 10.1093/jnci/87.20.1558-a |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0027-8874 |
| ispartof | JNCI : Journal of the National Cancer Institute, 1995-10, Vol.87 (20), p.1558-1559 |
| issn | 0027-8874 1460-2105 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77525403 |
| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Cancer Cellular biology Drug Resistance Drug therapy Fluorouracil - pharmacology Humans Letters to the editor Neoplasms - drug therapy Neoplasms - enzymology Neoplasms - physiopathology Quinazolines - pharmacology Thiophenes - pharmacology Thymidylate Synthase - analysis Thymidylate Synthase - antagonists & inhibitors Tumor Cells, Cultured |
| title | Fluorouracil: Active in ZD1694 (Tomudex)-Resistant Cell Lines With Markedly Elevated Thymidylate Synthase Levels |
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