Fluorouracil: Active in ZD1694 (Tomudex)-Resistant Cell Lines With Markedly Elevated Thymidylate Synthase Levels

Fluorouracil: Active in ZD1694 (Tomudex)-Resistant Cell Lines With Markedly Elevated Thymidylate Synthase Levels

A letter to the editor discusses ZD1694, which is a quinazoline folate that inhibits the catalytic activity of thymidylate synthase. ZD1694 has been safely administered to patients in trials.

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Bibliographische Detailangaben
Veröffentlicht in:JNCI : Journal of the National Cancer Institute 1995-10, Vol.87 (20), p.1558-1559
Hauptverfasser: JOHNSTON, PATRICK G., BEHAN, KATHERINE A., ALLEGRA, CARMEN J., DRAKE, JAMES C.
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Cellular biology
Drug Resistance
Drug therapy
Fluorouracil - pharmacology
Humans
Letters to the editor
Neoplasms - drug therapy
Neoplasms - enzymology
Neoplasms - physiopathology
Quinazolines - pharmacology
Thiophenes - pharmacology
Thymidylate Synthase - analysis
Thymidylate Synthase - antagonists & inhibitors
Tumor Cells, Cultured
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Beschreibung
Zusammenfassung:A letter to the editor discusses ZD1694, which is a quinazoline folate that inhibits the catalytic activity of thymidylate synthase. ZD1694 has been safely administered to patients in trials.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/87.20.1558-a