Evidence for a signal peptide at the amino-terminal end of human mitochondrial aldehyde dehydrogenase

A full-length cDNA clone coding for human mitochondrial aldehyde dehydrogenase (ALDH 1) was isolated from a human fetal muscle cDNA library. Sequence analysis revealed structural similarities between the amino-terminal end of ALDH I and other known targeting sequences responsible for protein uptake...

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Veröffentlicht in:	FEBS letters 1987-05, Vol.215 (2), p.233-236
Hauptverfasser:	Braun, Thomas, Bober, Eva, Singh, Surjit, Agarwal, Dharam P., Goedde, H.Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	aldehyde dehydrogenase Aldehyde Dehydrogenase - analysis Aldehyde dehydrogenase I Amino Acid Sequence Analytical, structural and metabolic biochemistry Biological and medical sciences cDNA cDNA sequence Cloning, Molecular DNA - analysis Enzymes and enzyme inhibitors Fundamental and applied biological sciences. Psychology genes Human Humans Leader peptide man mitochondria Mitochondria - enzymology nucleotide sequence Oxidoreductases Protein Sorting Signals - analysis
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Beschreibung
Zusammenfassung:	A full-length cDNA clone coding for human mitochondrial aldehyde dehydrogenase (ALDH 1) was isolated from a human fetal muscle cDNA library. Sequence analysis revealed structural similarities between the amino-terminal end of ALDH I and other known targeting sequences responsible for protein uptake into the mitochondria.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(87)80152-7