A form of human basic fibroblast growth factor with an extended amino terminus

The amino acid sequence of a human placental bFGF was determined by a combination of protein and cDNA sequencing. The placental bFGF consists of 157 amino acid residues with a calculated molecular weight of 17,464 and is highly homologous to bovine pituitary bFGF. The human protein contains an amino...

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Veröffentlicht in:	Biochemical and biophysical research communications 1987-04, Vol.144 (2), p.543-550
Hauptverfasser:	Sommer, Andreas, Brewer, Michael T., Thompson, Robert C., Moscatelli, David, Presta, Marco, Rifkin, Daniel B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Applied sciences Base Sequence Cattle Cloning, Molecular DNA - analysis Exact sciences and technology Female fibroblast growth factor Fibroblast Growth Factors - genetics Humans man Other techniques and industries Placenta Sequence Homology, Nucleic Acid Species Specificity
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Beschreibung
Zusammenfassung:	The amino acid sequence of a human placental bFGF was determined by a combination of protein and cDNA sequencing. The placental bFGF consists of 157 amino acid residues with a calculated molecular weight of 17,464 and is highly homologous to bovine pituitary bFGF. The human protein contains an amino terminal extension when compared to the sequence established for bovine bFGF (Esch et al., 1985) and to the sequence of the predicted translation product based on human bFGF cDNA clones (Abraham et al., 1986).
ISSN:	0006-291X 1090-2104
DOI:	10.1016/S0006-291X(87)80001-3