Serum Concentrations of Granulocyte Colony-Stimulating Factor (G-CSF) Determined by A Highly-Sensitive Chemiluminescent Immunoassay during the Clinical Course of Subacute Thyroiditis

Granulocyte colony-stimulating factor (G-CSF) concentrations in serum were determined for the first time by a newly developed and highly sensitive chemiluminescent immunoassay (the limitation of detection, 0.5pg/ml) in ten patients with subacute thyroiditis, during treatment with glucocorticoid or indomethacin. Before therapy, circulating neurophil counts significantly increased to 5.15±2.07× 103/μl compared with the convalescent phase (2.94±1.07×103/μl), and the data were correlated with individual serum G-CSF levels (r=0.854, P