A complex balanced chromosomal rearrangement in repeated abortions

A double balanced reciprocal translocation involving four chromosomes, t(1;19;6;14) (1p11; 19p11; 6q25; 14q21), was found in the phenotypically normal husband in a couple referred because of repeated abortions. Reciprocal translocations, t(6;14), had been transmitted by his mother, his father being...

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Veröffentlicht in:Human genetics 1987-04, Vol.75 (4), p.388-390
Hauptverfasser: BARROS, A, CARMO TAVARES, M, CASTEDO, S, SALOME PEREIRA, M, PURIFICACAO TAVARES, M, ALMEIDA E COSTA, M
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Sprache:eng
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Zusammenfassung:A double balanced reciprocal translocation involving four chromosomes, t(1;19;6;14) (1p11; 19p11; 6q25; 14q21), was found in the phenotypically normal husband in a couple referred because of repeated abortions. Reciprocal translocations, t(6;14), had been transmitted by his mother, his father being apparently homozygous for a translocation comprising pairs 1 and 19--t(1;19)(1;19). The genetic consequences of this complex chromosomal rearrangement are analyzed.
ISSN:0340-6717
1432-1203
DOI:10.1007/bf00284115