Synthesis and Antiviral Activity of Various Esters of 9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine

The synthesis and in vivo biological activity of a series of mono-O-, di-O-, and N2-acyl derivatives of 9-[(1,3-dihydro-2-propoxy)-methyl]guanine (DHPG) are described.

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of pharmaceutical sciences 1987-02, Vol.76 (2), p.180-184
Hauptverfasser:	Martin, John C., Tippie, Michael A., McGee, Danny P.C., Verheyden, Julien P.H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir - analogs & derivatives Acyclovir - chemical synthesis Acyclovir - pharmacology Animals Antiviral Agents - chemical synthesis Biological and medical sciences Chemical Phenomena Chemistry Esters Ganciclovir - analogs & derivatives General pharmacology Herpes Simplex - drug therapy Medical sciences Mice Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Simplexvirus - drug effects
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Beschreibung
Zusammenfassung:	The synthesis and in vivo biological activity of a series of mono-O-, di-O-, and N2-acyl derivatives of 9-[(1,3-dihydro-2-propoxy)-methyl]guanine (DHPG) are described.
ISSN:	0022-3549 1520-6017
DOI:	10.1002/jps.2600760221