Aromatization of 19-norandrogens by equine testicular microsomes
In the stallion testis, aromatase activity was localized in the microsomal fraction. Androgen aromatization occurred through the loss of 1 beta,2 beta hydrogen atoms and appeared to involve free sulfhydryl groups. A single enzyme system seemed to aromatize androgen and norandrogen at the same rate w...
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| Veröffentlicht in: | The Journal of biological chemistry 1987-04, Vol.262 (12), p.5717-5722 |
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| container_end_page | 5722 |
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| container_issue | 12 |
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| container_title | The Journal of biological chemistry |
| container_volume | 262 |
| creator | Gaillard, J.L. Silberzahn, P. |
| description | In the stallion testis, aromatase activity was localized in the microsomal fraction. Androgen aromatization occurred through the loss of 1 beta,2 beta hydrogen atoms and appeared to involve free sulfhydryl groups. A single enzyme system seemed to aromatize androgen and norandrogen at the same rate while having a much lower affinity for norandrogens. |
| doi_str_mv | 10.1016/S0021-9258(18)45634-7 |
| format | Article |
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Androgen aromatization occurred through the loss of 1 beta,2 beta hydrogen atoms and appeared to involve free sulfhydryl groups. A single enzyme system seemed to aromatize androgen and norandrogen at the same rate while having a much lower affinity for norandrogens.</description><identifier>ISSN: 0021-9258</identifier><identifier>EISSN: 1083-351X</identifier><identifier>DOI: 10.1016/S0021-9258(18)45634-7</identifier><identifier>PMID: 3571232</identifier><identifier>CODEN: JBCHA3</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Aging ; Analytical, structural and metabolic biochemistry ; Androgens ; Animals ; Aromatase - isolation & purification ; Aromatase - metabolism ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Horses ; Male ; Microsomes - enzymology ; Mitochondria - enzymology ; Other biological molecules ; Subcellular Fractions - enzymology ; Substrate Specificity ; Terpenes, steroids. 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Androgen aromatization occurred through the loss of 1 beta,2 beta hydrogen atoms and appeared to involve free sulfhydryl groups. A single enzyme system seemed to aromatize androgen and norandrogen at the same rate while having a much lower affinity for norandrogens.</description><subject>Aging</subject><subject>Analytical, structural and metabolic biochemistry</subject><subject>Androgens</subject><subject>Animals</subject><subject>Aromatase - isolation & purification</subject><subject>Aromatase - metabolism</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Horses</subject><subject>Male</subject><subject>Microsomes - enzymology</subject><subject>Mitochondria - enzymology</subject><subject>Other biological molecules</subject><subject>Subcellular Fractions - enzymology</subject><subject>Substrate Specificity</subject><subject>Terpenes, steroids. Hormones</subject><subject>Testis - enzymology</subject><subject>Testis - growth & development</subject><subject>Tritium</subject><issn>0021-9258</issn><issn>1083-351X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1rFTEUhoNY6rX6EwoDiuhiNCcfk5NVLUXbQsGFCu5CbibTG5mZtMmMUn-9mc7lbhsSsjjPOXnzEHIK9CNQaD59p5RBrZnE94AfhGy4qNUzsgGKvOYSfj0nmwPygrzM-TctS2g4JsdcKmCcbcjn8xQHO4V_5cSxil0Fuh5jsmOb4q0fc7V9qPz9HEZfTT5Pwc29TdUQXIo5Dj6_Iked7bN_vb9PyM-vX35cXNU33y6vL85vaie0nOq2laBQatFtW4ecW40CKUrgqAE1VbxTbYnLecdKOIGttxQdOsmw7I6fkHfr3LsU7-eSxAwhO9_3dvRxzkYpoWkj2JMgCMWYaBZQruDylZx8Z-5SGGx6MEDNotg8KjaLPwNoHhUbVfpO9w_M28G3h66901J_u6_b7GzfFZcu5AOGDFHBMubNiu3C7e5vSN5sQ3Q7PxjWMAPMyJU6Wylf3P4JPpnsgh-db0uHm0wbwxNx_wN51KGD</recordid><startdate>19870425</startdate><enddate>19870425</enddate><creator>Gaillard, J.L.</creator><creator>Silberzahn, P.</creator><general>Elsevier Inc</general><general>American Society for Biochemistry and Molecular Biology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19870425</creationdate><title>Aromatization of 19-norandrogens by equine testicular microsomes</title><author>Gaillard, J.L. ; Silberzahn, P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-dd5178594fbdc833a98480851389189073f7d00233f235748dea08c8c528528f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Aging</topic><topic>Analytical, structural and metabolic biochemistry</topic><topic>Androgens</topic><topic>Animals</topic><topic>Aromatase - isolation & purification</topic><topic>Aromatase - metabolism</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Horses</topic><topic>Male</topic><topic>Microsomes - enzymology</topic><topic>Mitochondria - enzymology</topic><topic>Other biological molecules</topic><topic>Subcellular Fractions - enzymology</topic><topic>Substrate Specificity</topic><topic>Terpenes, steroids. Hormones</topic><topic>Testis - enzymology</topic><topic>Testis - growth & development</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaillard, J.L.</creatorcontrib><creatorcontrib>Silberzahn, P.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of biological chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gaillard, J.L.</au><au>Silberzahn, P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Aromatization of 19-norandrogens by equine testicular microsomes</atitle><jtitle>The Journal of biological chemistry</jtitle><addtitle>J Biol Chem</addtitle><date>1987-04-25</date><risdate>1987</risdate><volume>262</volume><issue>12</issue><spage>5717</spage><epage>5722</epage><pages>5717-5722</pages><issn>0021-9258</issn><eissn>1083-351X</eissn><coden>JBCHA3</coden><abstract>In the stallion testis, aromatase activity was localized in the microsomal fraction. 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| ispartof | The Journal of biological chemistry, 1987-04, Vol.262 (12), p.5717-5722 |
| issn | 0021-9258 1083-351X |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Aging Analytical, structural and metabolic biochemistry Androgens Animals Aromatase - isolation & purification Aromatase - metabolism Biological and medical sciences Fundamental and applied biological sciences. Psychology Horses Male Microsomes - enzymology Mitochondria - enzymology Other biological molecules Subcellular Fractions - enzymology Substrate Specificity Terpenes, steroids. Hormones Testis - enzymology Testis - growth & development Tritium |
| title | Aromatization of 19-norandrogens by equine testicular microsomes |
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