Aromatization of 19-norandrogens by equine testicular microsomes

In the stallion testis, aromatase activity was localized in the microsomal fraction. Androgen aromatization occurred through the loss of 1 beta,2 beta hydrogen atoms and appeared to involve free sulfhydryl groups. A single enzyme system seemed to aromatize androgen and norandrogen at the same rate w...

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Veröffentlicht in:	The Journal of biological chemistry 1987-04, Vol.262 (12), p.5717-5722
Hauptverfasser:	Gaillard, J.L., Silberzahn, P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Analytical, structural and metabolic biochemistry Androgens Animals Aromatase - isolation & purification Aromatase - metabolism Biological and medical sciences Fundamental and applied biological sciences. Psychology Horses Male Microsomes - enzymology Mitochondria - enzymology Other biological molecules Subcellular Fractions - enzymology Substrate Specificity Terpenes, steroids. Hormones Testis - enzymology Testis - growth & development Tritium
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Beschreibung
Zusammenfassung:	In the stallion testis, aromatase activity was localized in the microsomal fraction. Androgen aromatization occurred through the loss of 1 beta,2 beta hydrogen atoms and appeared to involve free sulfhydryl groups. A single enzyme system seemed to aromatize androgen and norandrogen at the same rate while having a much lower affinity for norandrogens.
ISSN:	0021-9258 1083-351X
DOI:	10.1016/S0021-9258(18)45634-7