Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in exfoliated cells

Recognition of cervical neoplasia by the estimation of a free-radical reaction product (octadeca-9,11-dienoic acid) in exfoliated cells

The molar ratio between a diene-conjugated linoleic-acid isomer (18 : 2(9,11)) and the parent linoleic acid (18 : 2(9,12)), both esterified as phospholipids, was significantly different in exfoliated cells from normal cervices and from cervices with colposcopic and cytological evidence of precancer....

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Veröffentlicht in:Clinica chimica acta 1987-03, Vol.163 (2), p.149-152
Hauptverfasser: Tay, S.K., Singer, A., Griffin, J.F.A., Wickens, D.G., Dormandy, T.L.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Biological and medical sciences
Biopsy
Cancer
Cervix
Colposcopy
Diene conjugation
Female
Female genital diseases
Free radical
Gynecology. Andrology. Obstetrics
Humans
Linoleic Acid
Linoleic Acids - analysis
Linoleic Acids, Conjugated
Medical sciences
Non tumoral diseases
Precancerous Conditions - diagnosis
Uterine Cervical Neoplasms - diagnosis
Vaginal Smears
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Zusammenfassung:The molar ratio between a diene-conjugated linoleic-acid isomer (18 : 2(9,11)) and the parent linoleic acid (18 : 2(9,12)), both esterified as phospholipids, was significantly different in exfoliated cells from normal cervices and from cervices with colposcopic and cytological evidence of precancer. The measurement may provide a simple and perhaps improved alternative to cytological screening.
ISSN:0009-8981
1873-3492
DOI:10.1016/0009-8981(87)90017-9