Comparison of stimulants and hallucinogens on shuttle avoidance in rats

1. 1. Rats were trained to a high level of performance of a conditioned avoidance response in a shuttlebox to test effects of several classical stimulants in comparison to a variety of hallucinogens. 2. 2. A previously-reported biphasic pattern of effects of mescaline on shuttle avoidance was replic...

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Veröffentlicht in:	General pharmacology 1987, Vol.18 (2), p.123-128
Hauptverfasser:	Davis, W.M., Hatoum, H.T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamines - pharmacology Animals Avoidance Learning - drug effects Central Nervous System Agents - pharmacology Conditioning (Psychology) - drug effects Hallucinogens - pharmacology Male Mescaline - pharmacology Psychotropic Drugs - pharmacology Rats Stimulation, Chemical Tryptamines - pharmacology
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Zusammenfassung:	1. 1. Rats were trained to a high level of performance of a conditioned avoidance response in a shuttlebox to test effects of several classical stimulants in comparison to a variety of hallucinogens. 2. 2. A previously-reported biphasic pattern of effects of mescaline on shuttle avoidance was replicated and extended to 12 other hallucinogens of both phenylethylamine and indolealkylamine classes. 3. 3. Response patterns of hallucinogens could be differentiated from 3 stimulants and from a methoxyamphetamine compound that lacks hallucinogenic activity.
ISSN:	0306-3623 1879-0011
DOI:	10.1016/0306-3623(87)90237-0