Effect of disease and drug treatment on blood serotonin and monoamine oxidase B activity in Parkinson's disease

Serotonin (5-hydroxytryptamine, 5HT) content and monoamine oxidase (MAO) activity were determined in whole blood of patients with Parkinson's disease (PD) with and without drug treatment and compared with controls. From that comparison a significant reduction in platelet 5HT became apparent in...

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Veröffentlicht in:	Clinical neurology and neurosurgery 1995-05, Vol.97 (2), p.131-133
Hauptverfasser:	van Kempen, G.M.J., Janjua, R., Roos, R.A.C.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-hydroxytryptamine Adult Aged Amantadine - administration & dosage Amantadine - pharmacology Amantadine - therapeutic use Biological and medical sciences Blood Platelets - drug effects Bromocriptine - administration & dosage Bromocriptine - pharmacology Bromocriptine - therapeutic use Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Drug effects Drug Therapy, Combination Female Humans Levodopa - pharmacology Levodopa - therapeutic use Male Medical sciences Middle Aged Monoamine oxidase Monoamine Oxidase - metabolism Neurology Parkinson Disease - drug therapy Parkinson's disease Selegiline Selegiline - administration & dosage Selegiline - pharmacology Selegiline - therapeutic use Serotonin Serotonin - metabolism Treatment Outcome
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Zusammenfassung:	Serotonin (5-hydroxytryptamine, 5HT) content and monoamine oxidase (MAO) activity were determined in whole blood of patients with Parkinson's disease (PD) with and without drug treatment and compared with controls. From that comparison a significant reduction in platelet 5HT became apparent in PD. Selegiline, which was always used in combination with l-dopa, not only inhibited MAO activity, as expected, but it also appeared to induce an increase in 5HT content.
ISSN:	0303-8467 1872-6968
DOI:	10.1016/0303-8467(95)00011-8