Acute and Chronic Experimental Trypanosoma cruzi Infection in the Rat. Response to Systemic Treatment with Recombinant Rat Interferon-Gamma
We examined the effects of recombinant rat inteferon-gamma (IFN-γ) injections on the parasitologic, serologic, immunologic and histopathologic features of acute and chronic experimental Trypanosoma cruzi (T. cruzi) infections in“l”rats. Upon infection at weaning, two rat groups were allocated to rec...
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| Veröffentlicht in: | MICROBIOLOGY and IMMUNOLOGY 1995, Vol.39(4), pp.275-281 |
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| creator | Revelli, Silvia Davila, Hector Ferro, Maria E. Romero-Piffiguer, Marta Musso, Orlando Valenti, Jose Bernabo, Jorge Falcoff, Ernesto Wietzerbin, Jeanne Bottasso, Oscar |
| description | We examined the effects of recombinant rat inteferon-gamma (IFN-γ) injections on the parasitologic, serologic, immunologic and histopathologic features of acute and chronic experimental Trypanosoma cruzi (T. cruzi) infections in“l”rats. Upon infection at weaning, two rat groups were allocated to receive a 20-day cycle of IFN-γ injections, 20, 000IU/rat each, which started at 1, and 7 days post-infection (pi). Treatment with IFN-γ, initiated at either 1 or 7 days pi, resulted in comparatively lower peak parasitemias (P |
| doi_str_mv | 10.1111/j.1348-0421.1995.tb02201.x |
| format | Article |
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Upon infection at weaning, two rat groups were allocated to receive a 20-day cycle of IFN-γ injections, 20, 000IU/rat each, which started at 1, and 7 days post-infection (pi). Treatment with IFN-γ, initiated at either 1 or 7 days pi, resulted in comparatively lower peak parasitemias (P<0.02) but in similar levels of anti-T. cruzi circulating antibodies and serum IFN-γ activities. The latter appeared significantly increased during acute infection whereas biologically active tumor necrosis factor was virtually undetectable in serum from infected rats regardless of whether they had been given IFN-γ or not. The prevalence of chronic focal myocarditis in IFN-γ-treated infected rats showed no differences with respect to the one recorded in control-infected counterparts. The inverse CD4/CD8 ratio of spleen and lymph node T cells that usually accompanies chronic infection was reversed by IFN-γ. Mononuclear cells carrying class II I-A and I-E molecules, that were found to have increased at both compartments, appeared also modified upon IFN-γ treatment with an overincrease of I-A-positive cells, and a normalization of I-E-bearing cells.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/j.1348-0421.1995.tb02201.x</identifier><identifier>PMID: 7651241</identifier><identifier>CODEN: MIIMDV</identifier><language>eng</language><publisher>Tokyo: Blackwell Publishing Ltd</publisher><subject>Acute Disease ; AIDS/HIV ; Animals ; Antibodies, Protozoan - analysis ; Biological and medical sciences ; CD4-CD8 Ratio ; Chagas Disease - immunology ; Chagas Disease - pathology ; Chagas Disease - therapy ; Chronic Disease ; Class II antigens ; Disease Models, Animal ; Experimental protozoal diseases and models ; Histocompatibility Antigens Class II - immunology ; Infectious diseases ; Interferon-gamma ; Interferon-gamma - analysis ; Interferon-gamma - therapeutic use ; Lymph Nodes - cytology ; Male ; Medical sciences ; Myocarditis ; Myocarditis - etiology ; Myocarditis - pathology ; Parasitemia - immunology ; Parasitemia - pathology ; Parasitemia - therapy ; Parasitic diseases ; Prevalence ; Protozoal diseases ; Rats ; Recombinant Proteins ; Spleen - cytology ; T-cell subsets ; T-Lymphocyte Subsets - immunology ; Trypanosoma cruzi ; Trypanosoma cruzi - drug effects ; Trypanosoma cruzi - immunology ; Tumor Necrosis Factor-alpha - analysis</subject><ispartof>MICROBIOLOGY and IMMUNOLOGY, 1995, Vol.39(4), pp.275-281</ispartof><rights>Center for Academic Publications Japan</rights><rights>owned by Center for Academic Publications Japan (Publisher)</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5931-12103ede0c2f8e7269d41daeaafb636ffd73e5f7ed05494a8c3b8893014610793</citedby><cites>FETCH-LOGICAL-c5931-12103ede0c2f8e7269d41daeaafb636ffd73e5f7ed05494a8c3b8893014610793</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1877,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3556160$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7651241$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Revelli, Silvia</creatorcontrib><creatorcontrib>Davila, Hector</creatorcontrib><creatorcontrib>Ferro, Maria E.</creatorcontrib><creatorcontrib>Romero-Piffiguer, Marta</creatorcontrib><creatorcontrib>Musso, Orlando</creatorcontrib><creatorcontrib>Valenti, Jose</creatorcontrib><creatorcontrib>Bernabo, Jorge</creatorcontrib><creatorcontrib>Falcoff, Ernesto</creatorcontrib><creatorcontrib>Wietzerbin, Jeanne</creatorcontrib><creatorcontrib>Bottasso, Oscar</creatorcontrib><title>Acute and Chronic Experimental Trypanosoma cruzi Infection in the Rat. Response to Systemic Treatment with Recombinant Rat Interferon-Gamma</title><title>MICROBIOLOGY and IMMUNOLOGY</title><addtitle>Microbiology and Immunology</addtitle><description>We examined the effects of recombinant rat inteferon-gamma (IFN-γ) injections on the parasitologic, serologic, immunologic and histopathologic features of acute and chronic experimental Trypanosoma cruzi (T. cruzi) infections in“l”rats. Upon infection at weaning, two rat groups were allocated to receive a 20-day cycle of IFN-γ injections, 20, 000IU/rat each, which started at 1, and 7 days post-infection (pi). Treatment with IFN-γ, initiated at either 1 or 7 days pi, resulted in comparatively lower peak parasitemias (P<0.02) but in similar levels of anti-T. cruzi circulating antibodies and serum IFN-γ activities. The latter appeared significantly increased during acute infection whereas biologically active tumor necrosis factor was virtually undetectable in serum from infected rats regardless of whether they had been given IFN-γ or not. The prevalence of chronic focal myocarditis in IFN-γ-treated infected rats showed no differences with respect to the one recorded in control-infected counterparts. The inverse CD4/CD8 ratio of spleen and lymph node T cells that usually accompanies chronic infection was reversed by IFN-γ. Mononuclear cells carrying class II I-A and I-E molecules, that were found to have increased at both compartments, appeared also modified upon IFN-γ treatment with an overincrease of I-A-positive cells, and a normalization of I-E-bearing cells.</description><subject>Acute Disease</subject><subject>AIDS/HIV</subject><subject>Animals</subject><subject>Antibodies, Protozoan - analysis</subject><subject>Biological and medical sciences</subject><subject>CD4-CD8 Ratio</subject><subject>Chagas Disease - immunology</subject><subject>Chagas Disease - pathology</subject><subject>Chagas Disease - therapy</subject><subject>Chronic Disease</subject><subject>Class II antigens</subject><subject>Disease Models, Animal</subject><subject>Experimental protozoal diseases and models</subject><subject>Histocompatibility Antigens Class II - immunology</subject><subject>Infectious diseases</subject><subject>Interferon-gamma</subject><subject>Interferon-gamma - analysis</subject><subject>Interferon-gamma - therapeutic use</subject><subject>Lymph Nodes - cytology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myocarditis</subject><subject>Myocarditis - etiology</subject><subject>Myocarditis - pathology</subject><subject>Parasitemia - immunology</subject><subject>Parasitemia - pathology</subject><subject>Parasitemia - therapy</subject><subject>Parasitic diseases</subject><subject>Prevalence</subject><subject>Protozoal diseases</subject><subject>Rats</subject><subject>Recombinant Proteins</subject><subject>Spleen - cytology</subject><subject>T-cell subsets</subject><subject>T-Lymphocyte Subsets - immunology</subject><subject>Trypanosoma cruzi</subject><subject>Trypanosoma cruzi - drug effects</subject><subject>Trypanosoma cruzi - immunology</subject><subject>Tumor Necrosis Factor-alpha - analysis</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkt9u0zAUhyMEGmXwCEgWQoibBP9LHHPFVHVdpQ3QVgR3luucUJfEKbartbwCL41Lq4orEL6IrZzvfCfKz1n2guCCpPVmVRDG6xxzSgoiZVnEBaYUk2L7IBudSg-zEWZ1mZcVxo-zJyGsMKaC1vwsOxNVSSgno-znhdlEQNo1aLz0g7MGTbZr8LYHF3WH5n631m4IQ6-R8ZsfFs1cCybawSHrUFwCutWxQLcQ1oMLgOKA7nYhQp9Mcw867kXo3sZlYszQL6zT6UVqSqYIvoU0NZ_qvtdPs0et7gI8O-7n2afLyXx8lV9_mM7GF9e5KSUjOaEEM2gAG9rWIGglG04aDVq3i4pVbdsIBmUroMEll1zXhi3qWjJMeEWwkOw8e3Xwrv3wfQMhqt4GA12nHQyboITgAnPG_gmSSspaiiqBr_8OckkrxmVNE_r2gBo_hOChVev0s7XfKYLVPl21UvsI1T5CtU9XHdNV29T8_Dhns-ihObUe40z1l8e6DkZ3rdfO2HDCWFlWpMIJe3fA7m0Hu__4AHUzu_l9TIrJQbEKUX-Fk0P7aE0Hqk83yhIphGJS8cODivJUN0vtFbjkyQ8em-7M9g_NN1UJlho-v5-qj1_urqZ8StQl-wXm3uqf</recordid><startdate>19950101</startdate><enddate>19950101</enddate><creator>Revelli, Silvia</creator><creator>Davila, Hector</creator><creator>Ferro, Maria E.</creator><creator>Romero-Piffiguer, Marta</creator><creator>Musso, Orlando</creator><creator>Valenti, Jose</creator><creator>Bernabo, Jorge</creator><creator>Falcoff, Ernesto</creator><creator>Wietzerbin, Jeanne</creator><creator>Bottasso, Oscar</creator><general>Blackwell Publishing Ltd</general><general>Center For Academic Publications Japan</general><general>Center for Academic Publications Japan</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19950101</creationdate><title>Acute and Chronic Experimental Trypanosoma cruzi Infection in the Rat. 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Response to Systemic Treatment with Recombinant Rat Interferon-Gamma</atitle><jtitle>MICROBIOLOGY and IMMUNOLOGY</jtitle><addtitle>Microbiology and Immunology</addtitle><date>1995-01-01</date><risdate>1995</risdate><volume>39</volume><issue>4</issue><spage>275</spage><epage>281</epage><pages>275-281</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><coden>MIIMDV</coden><abstract>We examined the effects of recombinant rat inteferon-gamma (IFN-γ) injections on the parasitologic, serologic, immunologic and histopathologic features of acute and chronic experimental Trypanosoma cruzi (T. cruzi) infections in“l”rats. Upon infection at weaning, two rat groups were allocated to receive a 20-day cycle of IFN-γ injections, 20, 000IU/rat each, which started at 1, and 7 days post-infection (pi). Treatment with IFN-γ, initiated at either 1 or 7 days pi, resulted in comparatively lower peak parasitemias (P<0.02) but in similar levels of anti-T. cruzi circulating antibodies and serum IFN-γ activities. The latter appeared significantly increased during acute infection whereas biologically active tumor necrosis factor was virtually undetectable in serum from infected rats regardless of whether they had been given IFN-γ or not. The prevalence of chronic focal myocarditis in IFN-γ-treated infected rats showed no differences with respect to the one recorded in control-infected counterparts. The inverse CD4/CD8 ratio of spleen and lymph node T cells that usually accompanies chronic infection was reversed by IFN-γ. Mononuclear cells carrying class II I-A and I-E molecules, that were found to have increased at both compartments, appeared also modified upon IFN-γ treatment with an overincrease of I-A-positive cells, and a normalization of I-E-bearing cells.</abstract><cop>Tokyo</cop><pub>Blackwell Publishing Ltd</pub><pmid>7651241</pmid><doi>10.1111/j.1348-0421.1995.tb02201.x</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | MICROBIOLOGY and IMMUNOLOGY, 1995, Vol.39(4), pp.275-281 |
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| language | eng |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Alma/SFX Local Collection |
| subjects | Acute Disease AIDS/HIV Animals Antibodies, Protozoan - analysis Biological and medical sciences CD4-CD8 Ratio Chagas Disease - immunology Chagas Disease - pathology Chagas Disease - therapy Chronic Disease Class II antigens Disease Models, Animal Experimental protozoal diseases and models Histocompatibility Antigens Class II - immunology Infectious diseases Interferon-gamma Interferon-gamma - analysis Interferon-gamma - therapeutic use Lymph Nodes - cytology Male Medical sciences Myocarditis Myocarditis - etiology Myocarditis - pathology Parasitemia - immunology Parasitemia - pathology Parasitemia - therapy Parasitic diseases Prevalence Protozoal diseases Rats Recombinant Proteins Spleen - cytology T-cell subsets T-Lymphocyte Subsets - immunology Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - immunology Tumor Necrosis Factor-alpha - analysis |
| title | Acute and Chronic Experimental Trypanosoma cruzi Infection in the Rat. Response to Systemic Treatment with Recombinant Rat Interferon-Gamma |
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