Acute and Chronic Experimental Trypanosoma cruzi Infection in the Rat. Response to Systemic Treatment with Recombinant Rat Interferon-Gamma

We examined the effects of recombinant rat inteferon-gamma (IFN-γ) injections on the parasitologic, serologic, immunologic and histopathologic features of acute and chronic experimental Trypanosoma cruzi (T. cruzi) infections in“l”rats. Upon infection at weaning, two rat groups were allocated to rec...

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Veröffentlicht in:	MICROBIOLOGY and IMMUNOLOGY 1995, Vol.39(4), pp.275-281
Hauptverfasser:	Revelli, Silvia, Davila, Hector, Ferro, Maria E., Romero-Piffiguer, Marta, Musso, Orlando, Valenti, Jose, Bernabo, Jorge, Falcoff, Ernesto, Wietzerbin, Jeanne, Bottasso, Oscar
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease AIDS/HIV Animals Antibodies, Protozoan - analysis Biological and medical sciences CD4-CD8 Ratio Chagas Disease - immunology Chagas Disease - pathology Chagas Disease - therapy Chronic Disease Class II antigens Disease Models, Animal Experimental protozoal diseases and models Histocompatibility Antigens Class II - immunology Infectious diseases Interferon-gamma Interferon-gamma - analysis Interferon-gamma - therapeutic use Lymph Nodes - cytology Male Medical sciences Myocarditis Myocarditis - etiology Myocarditis - pathology Parasitemia - immunology Parasitemia - pathology Parasitemia - therapy Parasitic diseases Prevalence Protozoal diseases Rats Recombinant Proteins Spleen - cytology T-cell subsets T-Lymphocyte Subsets - immunology Trypanosoma cruzi Trypanosoma cruzi - drug effects Trypanosoma cruzi - immunology Tumor Necrosis Factor-alpha - analysis
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Zusammenfassung:	We examined the effects of recombinant rat inteferon-gamma (IFN-γ) injections on the parasitologic, serologic, immunologic and histopathologic features of acute and chronic experimental Trypanosoma cruzi (T. cruzi) infections in“l”rats. Upon infection at weaning, two rat groups were allocated to receive a 20-day cycle of IFN-γ injections, 20, 000IU/rat each, which started at 1, and 7 days post-infection (pi). Treatment with IFN-γ, initiated at either 1 or 7 days pi, resulted in comparatively lower peak parasitemias (P
ISSN:	0385-5600 1348-0421
DOI:	10.1111/j.1348-0421.1995.tb02201.x