Uptake and Release of Ca2+ in Chemically Skinned Aortic Strips from Spontaneously Hypertensive (SHR) and Normotensive (WKY) Rats

The uptake and release of Ca2+ were studied in EGTA-skinned aortic strips from spontaneously hypertensive rats (SHR strain: SAP=191±5mmHg, n=27) and normotensive control rats (WKY strain: SAP=131±2mmHg, n=25). 45Ca uptake was measured as a function of time (0.5 to 30min.), at pCa 6.6, in the presenc...

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Veröffentlicht in:	Japanese Heart Journal 1995, Vol.36(3), pp.377-388
Hauptverfasser:	AIELLO, Ernesto A., GRASSI, Angela O.
Format:	Artikel
Sprache:	eng
Schlagworte:	45Ca uptake and release Animals Aorta - metabolism Arterial hypertension. Arterial hypotension Biological and medical sciences Biological Transport Blood and lymphatic vessels Caffeine - pharmacology Calcium - metabolism Cardiology. Vascular system Experimental diseases Hypertension - metabolism Inositol Phosphates - pharmacology Male Medical sciences Muscle, Smooth, Vascular - metabolism Norepinephrine - pharmacology Rats Rats, Inbred SHR Rats, Inbred WKY Sarcoplasmic reticulum Sarcoplasmic Reticulum - metabolism Skinned smooth vascular muscle Spontaneously hypertensive rats
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Zusammenfassung:	The uptake and release of Ca2+ were studied in EGTA-skinned aortic strips from spontaneously hypertensive rats (SHR strain: SAP=191±5mmHg, n=27) and normotensive control rats (WKY strain: SAP=131±2mmHg, n=25). 45Ca uptake was measured as a function of time (0.5 to 30min.), at pCa 6.6, in the presence of 10mM of K oxalate. Skinned aortic strips of SHRs accumulated more Ca2+ after 30min of uptake than those of WKY rats (0.66±0.05 vs 0.52±0.03nmole.mg-1 wet tissue; p
ISSN:	0021-4868 1348-673X
DOI:	10.1536/ihj.36.377