Randomized phase III trial of single versus multiple chemotherapeutic treatment following surgery and during radiotherapy for patients with anaplastic gliomas

In 81 patients with anaplastic supratentorial gliomas, single versus multiple chemotherapeutic agents were selected for treatment following surgery and during radiotherapy in a prospective randomized study. Time to treatment failure and survival were not significantly enhanced by multiple agent chem...

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Veröffentlicht in:	Surgical neurology 1987-05, Vol.27 (5), p.430-432
Hauptverfasser:	Mahaley, M.S., Whaley, Robert A., Krigman, Martin R., Bouldin, Thomas W., Bertsch, Linda, Cush, Sharon
Format:	Artikel
Sprache:	eng
Schlagworte:	Anaplastic gliomas Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Brain Neoplasms - drug therapy Brain Neoplasms - radiotherapy Brain Neoplasms - surgery Carmustine - therapeutic use Clinical Trials as Topic Combined Modality Therapy Glioma - drug therapy Glioma - radiotherapy Glioma - surgery Humans Hydroxyurea - therapeutic use Medical sciences Methylprednisolone - therapeutic use Middle Aged Mitolactol - therapeutic use Multiple agent chemotherapy Neurology Procarbazine - therapeutic use Random Allocation Teniposide - therapeutic use Tomography, X-Ray Computed Tumors of the nervous system. Phacomatoses
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Zusammenfassung:	In 81 patients with anaplastic supratentorial gliomas, single versus multiple chemotherapeutic agents were selected for treatment following surgery and during radiotherapy in a prospective randomized study. Time to treatment failure and survival were not significantly enhanced by multiple agent chemotherapy, as administered in this study.
ISSN:	0090-3019 1879-3339
DOI:	10.1016/0090-3019(87)90248-5