Proteins that bind serotonin in the nervous system of Aplysia californica

The central nervous system of Aplysia has been found to contain two forms of proteins that bind serotonin with high affinity. These proteins share several similarities with the serotonin binding proteins that have been isolated from the vertebrate nervous system. Their ability to bind serotonin is e...

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Veröffentlicht in:	Neuroscience letters 1987-03, Vol.74 (3), p.257-261
Hauptverfasser:	Tamir, H., Liu, K.P., Weiss, K.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Aplysia Aplysia californica Biological and medical sciences Carrier Proteins - isolation & purification Carrier Proteins - metabolism Fundamental and applied biological sciences. Psychology Ganglia - analysis Ganglia - metabolism Invertebrates Mollusca Nerve Tissue Proteins - isolation & purification Nerve Tissue Proteins - metabolism Physiology. Development Protein Binding Serotonergic neuron Serotonin Serotonin - metabolism Serotonin binding protein
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Beschreibung
Zusammenfassung:	The central nervous system of Aplysia has been found to contain two forms of proteins that bind serotonin with high affinity. These proteins share several similarities with the serotonin binding proteins that have been isolated from the vertebrate nervous system. Their ability to bind serotonin is enhanced by Fe 2+ and inhibited by Na +,-SH reagents as well as reserpine and N-acetyl-5-hydroxytryptophyl-5-hydroxytryp-tophanamide.
ISSN:	0304-3940 1872-7972
DOI:	10.1016/0304-3940(87)90306-5