Role of Calcium and Protein Kinase C in the Activation of T Cells in Takayasu's Arteritis

Role of Calcium and Protein Kinase C in the Activation of T Cells in Takayasu's Arteritis

The roles of protein kinase C and calcium in the T cells of patients suffering from Takayasu's arteritis (TA) in response to the mitogens phorbolmyristate acetate (PMA) and streptococcal antigens have been studied. In TA there was an increased basal activity of protein kinase C (1.074±0.223nmol...

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Veröffentlicht in:Japanese Heart Journal 1995, Vol.36(3), pp.341-348
Hauptverfasser: DHAR, Jyoti, GANGULY, Nirmal K., KUMARI, Savita, SHARMA, Bal Krishan
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Biological and medical sciences
Blood and lymphatic vessels
Calcium - physiology
Cardiology. Vascular system
Child
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Female
Humans
Intracellular calcium
Lymphocyte Activation
Male
Medical sciences
Mitogens - pharmacology
Protein kinase C
Protein Kinase C - physiology
Signal Transduction
T-Lymphocytes - immunology
Takayasu Arteritis - blood
Takayasu Arteritis - immunology
Takayasu's arteritis
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Zusammenfassung:The roles of protein kinase C and calcium in the T cells of patients suffering from Takayasu's arteritis (TA) in response to the mitogens phorbolmyristate acetate (PMA) and streptococcal antigens have been studied. In TA there was an increased basal activity of protein kinase C (1.074±0.223nmoles/mg protein/min) as compared with that of controls (0.570±12) (p
ISSN:0021-4868
1348-673X
DOI:10.1536/ihj.36.341