Stimulation of T Lymphocyte-Dependent Differentiation of Activated Human B Lymphocytes by Plasmodium falciparum Supernatants

In the present study, the authors investigated whether P. falciparum moieties could induce the differentiation of activated B cells into plasma cells. They show that this differentiation is dependent on the activation of T cells by Plasmodium -derived material.

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Bibliographische Detailangaben
Veröffentlicht in:	The Journal of infectious diseases 1987-05, Vol.155 (5), p.1037-1040
Hauptverfasser:	Ballet, Jean-Jacques, Jaureguiberry, Glnette, Deloron, Philippe, Agrapart, Monique
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies B lymphocytes B-Lymphocytes - cytology B-Lymphocytes - immunology Biological and medical sciences Cell Differentiation Cells, Cultured Concise Communications Cultured cells Erythrocytes Fundamental and applied biological sciences. Psychology Growth Substances - physiology Humans Immunoglobulins Immunoglobulins - biosynthesis Interleukin-4 Life cycle. Host-agent relationship. Pathogenesis Lymphocyte Activation Lymphocytes Lymphokines - physiology Malaria Parasites Parasitism Plasmodium falciparum Plasmodium falciparum - immunology Protozoa T lymphocytes T-Lymphocytes - immunology
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Beschreibung
Zusammenfassung:	In the present study, the authors investigated whether P. falciparum moieties could induce the differentiation of activated B cells into plasma cells. They show that this differentiation is dependent on the activation of T cells by Plasmodium -derived material.
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/155.5.1037