Antisulfatide antibody and neuropathy in a patient with Gaucher's disease

We report the presence of antisulfatide antibodies in a patient with type I Gaucher's disease and peripheral neuropathy. The association of Gaucher's disease with hypergammaglobulinemia and monoclonal gammopathy is well documented whereas its association with peripheral neuropathy is rare....

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Veröffentlicht in:	Neurology 1995-08, Vol.45 (8), p.1622-1623
Hauptverfasser:	MCALARNEY, T, PASTORES, G. M, HAYS, A. P, LATOV, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies - immunology Biological and medical sciences Errors of metabolism Female Gaucher Disease - complications Gaucher Disease - immunology Humans Lipids (lysosomal enzyme disorders, storage diseases) Medical sciences Metabolic diseases Middle Aged Peripheral Nervous System Diseases - complications Sulfoglycosphingolipids - immunology
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Zusammenfassung:	We report the presence of antisulfatide antibodies in a patient with type I Gaucher's disease and peripheral neuropathy. The association of Gaucher's disease with hypergammaglobulinemia and monoclonal gammopathy is well documented whereas its association with peripheral neuropathy is rare. We discuss whether antibodies directed against the sulfatide antigen are related to Gaucher's disease or are a coincidental association.
ISSN:	0028-3878 1526-632X
DOI:	10.1212/WNL.45.8.1622