IDENTIFICATION OF NOVEL ERYTHROMYCIN DERIVATIVES IN MOTHER LIQUOR CONCENTRATES OF STREPTOMYCES ERYTHRAEUS

The identification of five novel compounds, pseudo-erythromycin A-6, 9-hemiketal, 8, 9-anhydro-pseudo-erythromycin A-6, 9-hemiketal, 8, 9-anhydro-pseudo-N-demethylery thromycin A-6, 9-hemiketal, 5-O-β-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyc...

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Veröffentlicht in:	Journal of antibiotics 1987/01/25, Vol.40(1), pp.1-6
Hauptverfasser:	KIBWAGE, ISAAC O., JANSSEN, GERARD, BUSSON, ROGER, HOOGMARTENS, Jos, VANDERHAEGHE, HUBERT, VERBIST, LUDO
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacteria - drug effects Biological and medical sciences Culture Media Erythromycin - analogs & derivatives Erythromycin - isolation & purification Erythromycin - pharmacology General pharmacology Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Streptomyces - analysis Structure-Activity Relationship
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Zusammenfassung:	The identification of five novel compounds, pseudo-erythromycin A-6, 9-hemiketal, 8, 9-anhydro-pseudo-erythromycin A-6, 9-hemiketal, 8, 9-anhydro-pseudo-N-demethylery thromycin A-6, 9-hemiketal, 5-O-β-D-desosaminylerythronolide A and 15-nor-erythromycin C, in mother liquor concentrates of Streptomyces erythraeus is described. The pseudo-erythromycin derivatives are characterized by a 12-membered macrocyclic ring as a result of C13→C11 trans-lactonization. The five compounds have very little antimicrobial activity.
ISSN:	0021-8820 1881-1469
DOI:	10.7164/antibiotics.40.1