THE COLLABORATION OF H-2 IDENTICAL BONE MARROW CELLS IN IN VIVO ANTITUMOR ACTIVITY OF IMMUNE MOUSE SPLENOCYTES

Antitumor activity of Meth A-immune BALB/c mouse spleen cells (Meth A-Im-SPL) was assayed by a Winn test in CD-1(nu/nu) or BALB/c(nu/nu) chimeric mice which were reconstituted with the bone marrow cells of various strains of mice. It was found that Meth A-Im-SPL (L3T4+ T cells) neutralized the tumor...

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Veröffentlicht in:	Japanese Journal of Cancer Research GANN 1987, Vol.78(2), pp.113-116
Hauptverfasser:	OZAWA, Hideki, IWAGUCHI, Takao, KATAOKA, Tateshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Differentiation, T-Lymphocyte Antigens, Surface - immunology Biological and medical sciences Bone Marrow - immunology Bone marrow cells Chimera Chimeric nude mice Epidemiology Female H-2 Antigens - immunology H-2 restriction In vivo tumor rejection Medical sciences Meth A Mice Mice, Inbred BALB C Neoplasms, Experimental - immunology Spleen - immunology T-Lymphocytes - immunology Tumors
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Zusammenfassung:	Antitumor activity of Meth A-immune BALB/c mouse spleen cells (Meth A-Im-SPL) was assayed by a Winn test in CD-1(nu/nu) or BALB/c(nu/nu) chimeric mice which were reconstituted with the bone marrow cells of various strains of mice. It was found that Meth A-Im-SPL (L3T4+ T cells) neutralized the tumor in collaboration with H-2 compatible bone marrow or bone marrow-derived cells.
ISSN:	0910-5050 1876-4673
DOI:	10.20772/cancersci1985.78.2_113