Comparison of two 99mTc(V)-dimercaptosuccinic acid preparations

99mTc(V)-DMSA labelled either by increasing the pH together with a low concentration of Sn, or by increasing the pH only are compared in vitro and in vivo. The gel chromatographic separation shows that after incubation with blood, all the 99mTc(V)-DMSA preparations are stable and do not bind to the...

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Veröffentlicht in:	International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes Applied radiation and isotopes, 1987, Vol.38 (1), p.13-18
Hauptverfasser:	Jeghers, O., Puttemans, N., Urbain, D., Lefebvre, J., Ham, H.R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Neoplasms - diagnostic imaging Bone Neoplasms - secondary Humans Hydrogen-Ion Concentration In Vitro Techniques Male Organometallic Compounds - isolation & purification Organometallic Compounds - metabolism Prostatic Neoplasms - diagnostic imaging Radionuclide Imaging Rats Rats, Inbred Strains Succimer - isolation & purification Succimer - metabolism Sulfhydryl Compounds Technetium Tc 99m Dimercaptosuccinic Acid Tissue Distribution
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Zusammenfassung:	99mTc(V)-DMSA labelled either by increasing the pH together with a low concentration of Sn, or by increasing the pH only are compared in vitro and in vivo. The gel chromatographic separation shows that after incubation with blood, all the 99mTc(V)-DMSA preparations are stable and do not bind to the plasma proteins. The behavior in rats as well as in clinical studies does not demonstrate any distinctive characteristics between the different radiomolecules. It seems that the pH of the solution is an important factor which controls the formation of 99mTc(V)-DMSA.
ISSN:	0883-2889
DOI:	10.1016/0883-2889(87)90229-2