Effects of acetylsalicylic acid on serotonin brain receptor subtypes

1. 1. The lysine salt of acetyl salicylic acid (ASA) at a dose equivalent to 400 mg/kg of acetyl salicylic acid (ASA) was intraperitoneally administered in rats. 2. 2. After 30 and 120min ASA did not modify the number of receptors nor the affinity of [ 3H]8-OH-DPAT binding sites in pons and cerebral...

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Veröffentlicht in:	General pharmacology 1995-07, Vol.26 (4), p.737-741
Hauptverfasser:	Sandrini, Maurizio, Vitale, Giovanni, Dondi, Milena, Pini, Luigi A.
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Hydroxy-2-(di-n-propylamino)tetralin - pharmacokinetics Acetylsalicyclic acid Analgesics - pharmacology Animals antinociception Aspirin - pharmacokinetics Aspirin - pharmacology Brain Chemistry - drug effects brain serotonin receptors Cerebral Cortex - drug effects Cerebral Cortex - metabolism Ketanserin - pharmacokinetics Male Membranes - drug effects Membranes - metabolism Pons - drug effects Pons - metabolism Rats Rats, Wistar Receptors, Serotonin - drug effects
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Zusammenfassung:	1. 1. The lysine salt of acetyl salicylic acid (ASA) at a dose equivalent to 400 mg/kg of acetyl salicylic acid (ASA) was intraperitoneally administered in rats. 2. 2. After 30 and 120min ASA did not modify the number of receptors nor the affinity of [ 3H]8-OH-DPAT binding sites in pons and cerebral cortex. On the other hand, the receptor number in the cortex membranes decreased significantly using [ 3H]ketanserin as ligand, while the receptor number in the pontine membranes did not change. 3. 3. These data support the involvement of central 5-HT receptors in the mode of action of ASA.
ISSN:	0306-3623 1879-0011
DOI:	10.1016/0306-3623(94)00252-I