Improved and large-scale synthesis of certain glycosyl cyanides. Synthesis of 2,5-anhydro-5-thio- d-allononitrile
The first synthesis of 2,5-anhydro-5-thio- d-allononitrile starting with l-lyxose, via a trifluoromethanesulfonic ester intermediate, has been accomplished. Methods have been developed to achieve a large-scale synthesis of 3,4,5,7-tetra- O-acetyl-2,6-anhydro- d- glycero- d- talo-heptononitrile ( 5)....
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Veröffentlicht in: | Carbohydrate research 1987-01, Vol.159 (1), p.81-94 |
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Hauptverfasser: | , , , , , |
Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The first synthesis of 2,5-anhydro-5-thio-
d-allononitrile starting with
l-lyxose,
via a trifluoromethanesulfonic ester intermediate, has been accomplished. Methods have been developed to achieve a large-scale synthesis of 3,4,5,7-tetra-
O-acetyl-2,6-anhydro-
d-
glycero-
d-
talo-heptononitrile (
5). An improved procedure has been developed to synthesize 2,5-anhydro-3,4,6-tri-
O-benzoyl-
d-gulononitrile (
9). The structures of
5 and the thioamide derivative from
9, 2,5-anhydro-3,4,6-tri-
O-benzoyl-
d-gulonothioamide, were confirmed by X-ray crystallographic analysis. |
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ISSN: | 0008-6215 1873-426X |
DOI: | 10.1016/S0008-6215(00)90007-7 |