Effects of treatment with scopolamine and naloxone, singly and in combination, on amygdala kindling

Scopolamine and naloxone were administered singly and in combination to different groups of rats undergoing electrical kindling of the amygdala. Scopolamine significantly reduced the maximal seizure stage attained during 15 drug sessions and increased the total number of afterdischarges required to...

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Veröffentlicht in:	Experimental neurology 1987-04, Vol.96 (1), p.97-103
Hauptverfasser:	Cain, Donald P., McKitrick, Douglas J., Desborough, Kathryn A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala - physiopathology Animals Biological and medical sciences Kindling, Neurologic - drug effects Male Medical sciences Membrane Potentials - drug effects Naloxone - pharmacology Nervous system involvement in other diseases. Miscellaneous Neurology Rats Receptors, Muscarinic - drug effects Scopolamine - pharmacology
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Zusammenfassung:	Scopolamine and naloxone were administered singly and in combination to different groups of rats undergoing electrical kindling of the amygdala. Scopolamine significantly reduced the maximal seizure stage attained during 15 drug sessions and increased the total number of afterdischarges required to kindle a generalized convulsion. Naloxone had a similar but weaker and nonsignificant effect. The results confirm that antagnism of muscarinic receptors by scopolamine retards amygdala kindling.
ISSN:	0014-4886 1090-2430
DOI:	10.1016/0014-4886(87)90171-3