Inhibition of taurocholate efflux from rat hepatic canalicular membrane vesicles by glutathione disulfide

In right-side out rat hepatic canalicular membrane vesicles glutathione disulfide (GSSG) inhibited the efflux of taurocholate approx. 70% in the presence or approx. 55% in the absence of a valinomycin-mediated K + diffusion potential; maximal inhibition occurred at 5 mM GSSG. The inhibition by GSSG...

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Veröffentlicht in:	FEBS letters 1987-03, Vol.213 (1), p.34-38
Hauptverfasser:	Griffiths, James C., Sies, Helmut, Meier, Peter J., Akerboom, Theodorus P.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bile Canaliculi - drug effects Bile Canaliculi - metabolism Bile Ducts, Intrahepatic - metabolism Biological and medical sciences Biological Transport, Active Dithioerythritol - pharmacology Dose-Response Relationship, Drug Ethylmaleimide - pharmacology Fundamental and applied biological sciences. Psychology Glutathione - analogs & derivatives Glutathione - pharmacology Glutathione Disulfide liver Liver. Bile. Biliary tracts Male Microscopy, Electron Rat canalicular membrane vesicle Rats Rats, Inbred Strains Taurocholate transport taurocholic acid Taurocholic Acid - metabolism Valinomycin - pharmacology Vertebrates: digestive system
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Zusammenfassung:	In right-side out rat hepatic canalicular membrane vesicles glutathione disulfide (GSSG) inhibited the efflux of taurocholate approx. 70% in the presence or approx. 55% in the absence of a valinomycin-mediated K + diffusion potential; maximal inhibition occurred at 5 mM GSSG. The inhibition by GSSG was abolished by dithioerythritol. Neither dithioerythritol alone nor GSH inhibited taurocholate efflux. S-(2,4-Dinitrophenyl) glutathione and N-ethylmaleimide showed intermediate inhibitory effects.
ISSN:	0014-5793 1873-3468
DOI:	10.1016/0014-5793(87)81460-6