Plasmodium berghei: Selection of Mefloquine-Resistant Parasites through Drug Pressure in Mosquitoes

Mefloquine is an antimalarial drug with schizonticidal activity on blood-stage parasites. Studies of the role of mefloquine on the development of Plasmodium berghei ANKA in Anopheles stephensi have been carried out that showed a dose-dependent effect on the sporogonic cycle of these parasites, with...

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Veröffentlicht in:	Experimental parasitology 1995-08, Vol.81 (1), p.55-62
Hauptverfasser:	Fonseca, L., Vigario, A.M., Seixas, E., Dorosario, V.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	ANIMAL DEVELOPMENTAL STAGES Animals Anopheles - parasitology ANOPHELES GAMBIAE Anopheles stephensi ANTIPROTOZOAIRE ANTIPROTOZOAL AGENTS CELL INVASION DOSAGE EFFECTS Dose-Response Relationship, Drug Drug Resistance DRUGS EFFICACY Erythrocytes - parasitology ETAPAS DEL DESARROLLO ANIMAL EXPERIMENTACION IN VIVO EXPERIMENTAL INFECTION EXPERIMENTATION IN VIVO GLANDE SALIVAIRE GLANDULAS SALIVALES IN VIVO EXPERIMENTATION INFECCION INFECCION EXPERIMENTAL INFECTION INFECTION EXPERIMENTALE Malaria - parasitology Malaria - physiopathology MEDICAMENT MEDICAMENTOS MEDICAMENTOS CONTRA PROTOZOARIOS Mefloquine - pharmacokinetics Mefloquine - pharmacology MICE OOCYTES OVA OVULE OVULO Parasitemia - blood Parasitemia - physiopathology PLASMODIUM BERGHEI Plasmodium berghei - drug effects Plasmodium berghei - growth & development Plasmodium berghei - physiology RATON RESISTANCE AUX PRODUITS CHIMIQUES RESISTANCE TO CHEMICALS RESISTENCIA A PRODUCTOS QUIMICOS SALIVARY GLANDS Salivary Glands - parasitology SOURIS SPOROZOA SPOROZOITES STADE DE DEVELOPPEMENT ANIMAL
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