Plasmodium berghei: Selection of Mefloquine-Resistant Parasites through Drug Pressure in Mosquitoes

Mefloquine is an antimalarial drug with schizonticidal activity on blood-stage parasites. Studies of the role of mefloquine on the development of Plasmodium berghei ANKA in Anopheles stephensi have been carried out that showed a dose-dependent effect on the sporogonic cycle of these parasites, with...

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Veröffentlicht in:	Experimental parasitology 1995-08, Vol.81 (1), p.55-62
Hauptverfasser:	Fonseca, L., Vigario, A.M., Seixas, E., Dorosario, V.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	ANIMAL DEVELOPMENTAL STAGES Animals Anopheles - parasitology ANOPHELES GAMBIAE Anopheles stephensi ANTIPROTOZOAIRE ANTIPROTOZOAL AGENTS CELL INVASION DOSAGE EFFECTS Dose-Response Relationship, Drug Drug Resistance DRUGS EFFICACY Erythrocytes - parasitology ETAPAS DEL DESARROLLO ANIMAL EXPERIMENTACION IN VIVO EXPERIMENTAL INFECTION EXPERIMENTATION IN VIVO GLANDE SALIVAIRE GLANDULAS SALIVALES IN VIVO EXPERIMENTATION INFECCION INFECCION EXPERIMENTAL INFECTION INFECTION EXPERIMENTALE Malaria - parasitology Malaria - physiopathology MEDICAMENT MEDICAMENTOS MEDICAMENTOS CONTRA PROTOZOARIOS Mefloquine - pharmacokinetics Mefloquine - pharmacology MICE OOCYTES OVA OVULE OVULO Parasitemia - blood Parasitemia - physiopathology PLASMODIUM BERGHEI Plasmodium berghei - drug effects Plasmodium berghei - growth & development Plasmodium berghei - physiology RATON RESISTANCE AUX PRODUITS CHIMIQUES RESISTANCE TO CHEMICALS RESISTENCIA A PRODUCTOS QUIMICOS SALIVARY GLANDS Salivary Glands - parasitology SOURIS SPOROZOA SPOROZOITES STADE DE DEVELOPPEMENT ANIMAL
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Zusammenfassung:	Mefloquine is an antimalarial drug with schizonticidal activity on blood-stage parasites. Studies of the role of mefloquine on the development of Plasmodium berghei ANKA in Anopheles stephensi have been carried out that showed a dose-dependent effect on the sporogonic cycle of these parasites, with changes in the numbers of oocysts and the extent of sporozoite invasion of salivary glands. In this study, we show that mefloquine-resistant P. berghei ANKA blood stage parasites could be selected through drug pressure during continuous cyclical transmission of Anopheles gambiae s.1.
ISSN:	0014-4894 1090-2449
DOI:	10.1006/expr.1995.1092